ArticleEuropean journal of orthodontics2025
GuREx-MIH: radiographic assessment of eruption patterns of second permanent molars and premolars in 11-year-olds after early extraction of the first permanent molar - a split-mouth trial.
Article in European journal of orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Orthodontic management in patients diagnosed with molar-incisor hypomineralisation (MIH): a systematic review and meta-analysis of clinical and epidemiological studies.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- GuREx-MIH: cost-effectiveness analysis of extraction versus restorative treatment for first permanent molars affected by Molar-Incisor Hypomineralisation in 11-year-old Swedish children.BMC oral health · 2026Trial
- Radiographic indicators of favorable second permanent molar eruption are infrequently present at the time of first permanent molar extraction: a retrospective study.BMC oral health · 2026Article
- Spontaneous Second Molar Migration After MIH-Affected First Molars Extraction: A Radiographic-Based Method Evaluation.Children (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesMolar-Incisor Hypomineralisation (MIH) affects 14% of the global population, often leading to compromised first permanent molars (FPM). Early extraction of severely affected FPMs may temporarily affect proper eruption and alignment of second permanent molars (SPM) and second premolars (SP). This study aimed to evaluate the eruption patterns of SPMs and SPs, and the overeruption of opposing FPMs, after early FPM extraction using panoramic radiographs in 11-year-old patients. A secondary aim was to assess radiographic quality for these evaluations. SUBJECTS AND
methodsThis split-mouth trial included patients aged 6-9 with severe MIH requiring FPM extraction. Panoramic radiographs were taken pre-extraction (T0) and at age 11 (T1) to measure eruption length and angulation of SPMs and SPs. Radiographs were analysed using Facad software, and imaging errors were recorded. Paired t-tests compared extraction and non-extraction sides.
resultsAmong 47 patients, 31 had maxillary and 25 mandibular FPM extractions. At T0, eruption length and angulation of SPMs and SPs were similar between sides. At T1, maxillary SPMs erupted faster (13.5mm vs. 10.8mm, p < 0.001) and more upright (72.9° vs. 62.1°, p < 0.001) on the extraction side, while SPs showed increased mesial angulation (82.5° vs. 89.3°, p < 0.05). Mandibular SPMs and SPs showed no differences. No overeruption of opposing FPMs was observed. Measurement reliability was excellent (ICC: 0.997-0.999), despite 75 of 94 radiographic contained errors. LIMITATIONS: The three-year follow-up limits long-term insights, and radiographic distortions may affect reliability.
conclusionsEarly FPM extraction impacts maxillary but not mandibular SPM and SP eruption patterns without causing overeruption of opposing FPMs by age 11. Radiographic techniques are essential to minimize incorrect patient positioning, as such factors may impact measurement reliability.
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