Evidence map›Paper›PMID 40810302›Full record

ArticleMagnetic resonance in medicine2026

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized

Abdullah S Bdaiwi, Matthew M Willmering, Riaz Hussain, Erik Hysinger, Jason C Woods, Laura L Walkup, Zackary I Cleveland

Abstract readComparative Study
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Deep Learning Reconstruction forMagnetic resonance in medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdullah S BdaiwiDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-7835-7032
Matthew M WillmeringDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-4356-9622
Riaz HussainDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0003-4406-2345
Erik HysingerDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jason C WoodsDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Laura L WalkupDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Zackary I ClevelandDivision of Pulmonary Medicine, Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-6195-9061

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
UTE MRI to monitor CF lung disease and response to CFTR modulation in young childrenR01HL131012 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, JASON C WOODS · 2016 to 2026
$6.8M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Imaging and Molecular Phenotyping of Cystic Fibrosis Lung DiseaseR01HL151588 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I, ZIADY, ASSEM G · 2021 to 2025
$3.9M
Validating Quantitative Magnetic Resonance Imaging Biomarkers of Idiopathic Pulmonary FibrosisR01HL143011 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2019 to 2023
$3.7M
A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung DiseaseR44HL123299 · NHLBI · POLAREAN, INC. · PI EMAMI, KIARASH · 2017 to 2019
$3.0M
Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRIR01HL166335 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Laura Lee Walkup · 2023 to 2026
$2.7M
Time-Resolved 129Xe Ventilation-Perfusion MRI in Models of Acute Lung InjuryR00HL111217 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI CLEVELAND, ZACKARY I · 2015 to 2017
$728k
Cystic Fibrosis Foundation CLEVEL16A0National Organization for Rare Disorders 20003NHLBI NIH HHS R00 HL111217NHLBI NIH HHS R01 HL126771NHLBI NIH HHS R01 HL131012NHLBI NIH HHS R01 HL143011NHLBI NIH HHS R01 HL151588NHLBI NIH HHS R01 HL166335NHLBI NIH HHS R44 HL123299NIBIB NIH HHS P41 EB013598NIH HHS 2R01HL126771NIH HHS R00HL111217NIH HHS R01HL131012NIH HHS R01HL143011NIH HHS R01HL151588NIH HHS R01HL166335NIH HHS R44HL123299University of Cincinnati Cancer Center
6 · The paper itself

Abstract

purposeReduced signal-to-noise ratio (SNR) in hyperpolarized

methodsThe DL denoising frameworks were trained and tested on 952

resultsDenoising methods significantly reduced noise SDs and enhanced SNR (p < 0.05) across all imaging types. Traditional ventilation model (Trad

conclusionsLow SNR may impair the potential of

Indexed as

Deep LearningImage Processing, Computer-AssistedLungMagnetic Resonance ImagingSupervised Machine LearningUnsupervised Machine LearningXenon IsotopesAdultAgedAlgorithmsDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedSignal-To-Noise RatioXenon-129Xenon Isotopesdeep learningdenoisehyperpolarized 129Xenoise reductionSNR enhancement

Identifiers

PMID40810302
PMCPMC12370284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.