ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Motor performance and its association with Alzheimer's-related biomarkers: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Greater Motor and Nonmotor Burden at Diagnosis Is Associated With Amyloid Copathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- [Early Alzheimer's disease recognition via multimodal hand movement quality assessment].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
introductionWith accumulating evidence that motor manifestations in Alzheimer's disease (AD) may emerge from AD pathology independent of other copathologies, we investigated the neural basis of motor dysfunction under the amyloid/tau/neurodegeneration (ATN) framework.
methodsThis study included 125 patients with AD, excluding individuals with severe leukoaraiosis or comorbid Lewy body features beyond Parkinsonism. Associations of ATN burden with motor dysfunction were tested using multivariate regression models, followed by mediation analyses exploring the cognitive contribution to these associations.
resultsTau burden in the prefrontal, sensorimotor, and parietal regions was associated with motor dysfunction independent of amyloid or neurodegeneration. The effect of parietal tau on motor function was fully mediated by visuospatial dysfunction, whereas prefrontal/sensorimotor tau exerted direct effects without cognitive mediation. DISCUSSION: Increased tau burden in the sensorimotor and frontoparietal association cortices may elicit motor dysfunction in AD through either cognition-dependent or cognition-independent mechanisms, with effects depending on the affected regions. HIGHLIGHTS: Tau burden was intimately associated with motor symptoms independent of Aβ or atrophy. Tau in sensorimotor and frontoparietal association cortices may elicit motor symptoms. Prefrontal/sensorimotor tau exerted cognition-independent effects on motor symptoms. Parietal tau indirectly influenced motor symptoms through visuospatial dysfunction. Parietal tau-related motor dysfunction may be partly explained by apraxic features.
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