Evidence map›Paper›PMID 40810237›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma.

Wang Siliang, M A Yushui, Liu Lei, Wang Pei, W U Jia, Jin Xing, Jin Qiang, Wang Congcong, Qin Chentai, Zheng Miaomiao and 5 more

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Wang SiliangCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
M A YushuiCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Liu LeiDepartment of Thoracic Surgery, the Affiliated Tumor Hospital of Nantong University, Nantong 226300, China.
Wang PeiTraditional Chinese Medicine department, the Affiliated Tumor Hospital of Nantong University, Nantong 226300, China.
W U JiaCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Jin XingCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Jin QiangCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Wang CongcongCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Qin ChentaiCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zheng MiaomiaoCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Yang XiDepartment of Oncology, Shanxi Provincial Hospital of Traditional Chinese Medicine, Shanxi 030001, China.
Pan JunDepartment of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
X U HanchenShanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation, Shanghai 200032, China.
Dong ChangshengCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Chen WenlianCancer Institute, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.

Funding

Antitumor Mechanism of Oleanolic Acid via Autophagy by Regulating Adenosine Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin- Unc51 Like Kinase 1 Pathway and Inhibiting Purine Salvage Pathway 82004177A special clinical research initiative for the health business sponsored by the Shanghai Municipal Health Commission 202040155Biological Basis of the Pathogenesis of Cancer Toxin in Traditional Chinese Medicine 2022YFC3500200Biological Basis of the Pathogenesis of Cancer Toxin in Traditional Chinese Medicine 2022YFC3500202Mechanistic Study of Methionine Cycle Modulating the Growth of Esophageal Squamous Cell Carcinoma through "DNA Methylation-DNA Stability-p53/p21-cell Cycle" Pathway 82002953Mechanistic Study of Renal Cancer Neoplastic Growth Driven by Glucose Transporter 5-Mediated Fructose Metabolism Reprogramming 31970708National Scientific and Technological Major Special Project of China: Shuang Huang Sheng Bai Oral Liquid: Efficacy and Safety Evaluation of Traditional Chinese Medicine Compound Based on Systems Biology Approaches 2019ZX09201004-002-013Natural Science Foundation-funded Project: Establishment of Syndrome-Disease Warning System and Investigation of the Clinical Features and Evolution Patterns of Traditional Chinese Medicine Syndromes in Esophageal Cancer under Modern Medical Diagnosis and Treatment 2023YFC3503200Natural Science Foundation-funded Project: Establishment of Syndrome-Disease Warning System and Investigation of the Clinical Features and Evolution Patterns of Traditional Chinese Medicine Syndromes in Esophageal Cancer under Modern Medical Diagnosis and Treatment 2023YFC3503201Natural Science Foundation-funded Project: Mechanistic Study of the Nucleolar Methyltransferase Fibrillarin to Promote Neoplastic Growth of Esophageal Squamous Cell Carcinoma via Activating Nucleoside Synthesis 32170778Scientific Research Project of Industry Development Center of Shanghai University of Traditional Chinese Medicine 602076DShanghai 13th Five-Year Plan Key Specialty of Traditional Chinese Medicine Oncology shslczdzk03701Shanghai Municipal Science and Technology Commissions Special Biomedical Technology Support Plan 20S31904100Shanghai "Science and Technology Innovation Action Plan" Medical Innovation Research Project--Shanghai Clinical Research Center of Traditional Chinese Medicine Oncology 21MC1930500Tracking Programme for Eastern Scholar at Shanghai Institutions of Higher Learning, Shanghai High-level Talent Leadership Programme of Traditional Chinese Medicine(ZY 2021-2023)-0403USP14 Cooperates with Ubiquitin C-Terminal Hydrolase L5 to Regulate Constitutive Photomorphogenic 9 Signalosome-mediated Programmed Death-Ligand 1 Deubiquitination and Promote Immune Evasion in Hepatocellular Carcinoma 81972214
6 · The paper itself

Abstract

objectiveTo uncover the biological foundation of the prevailing TCM syndrome in individuals with Esophageal squamous cell carcinoma (ESCC), Zhengxu Xieshi (ZXXS), which is characterized by a deficiency in vital

methodsWe investigated shifts in vital

resultsSerum metabolomic profiling highlighted the prevalent downregulation of differentially expressed metabolites in patient sera, in contrast to the upregulation observed in ESCC tissues, compared to their respective controls. Remarkably, the group of differential metabolites in the ESCC tissues was predominantly composed of amino acids. Thus, we focused on amino acid metabolism. Our integrative analysis showed the downregulation of a significant majority of disturbed amino acids in patient sera relative to the upregulation of an overwhelming proportion of perturbed amino acids within ESCC tissues. Enrichment analysis of these amino acids revealed seven metabolic pathways that contribute to the metabolism of antioxidants, energy intermediates, and biosynthetic precursors. Interestingly, these pathways displayed attenuation in patient sera but augmentation in ESCC tissues. Similarly, the proteomic data confirmed the activation of these pathways in ESCC tissues.

conclusionThis study presents a new perspective on the prevalence of ZXXS syndrome in patients with ESCC, contextualized within the realm of metabolic reprogramming. Specifically, diminished amino acid metabolism in the circulating blood corresponds to a deficiency in vital

Indexed as

Amino AcidsBiomarkers, TumorEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaAdultAgedFemaleHumansMaleMiddle AgedAmino AcidsBiomarkers, Tumoramino acid metabolismesophageal squamous cell carcinomaevilmetabolic reprogrammingvitalZhengxu Xieshi syndrome

Identifiers

PMID40810237
PMCPMC12340589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.