ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Clinical evaluation of strengthening spleen and draining dampness in the treatment of idiopathic membranous nephropathy: a retrospective 10-year follow-up study.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the 10-year therapeutic efficacy of Traditional Chinese Medicine (TCM) using the Strengthening Spleen and Draining Dampness therapy in the management of idiopathic membranous nephropathy (IMN).
methodsA single-center, retrospective analysis was conducted on patients diagnosed with IMN who met predefined inclusion and exclusion criteria. Data were collected from the Department of Nephrology at Longhua Hospital, affiliated with Shanghai University of Traditional Chinese Medicine, between January 2007 and December 2011. Clinical parameters including 24-h urinary protein, serum albumin, serum creatinine, and estimated glomerular filtration rate (eGFR, EPI) were assessed at baseline and at 1, 3, 5, and 10 years of follow-up. The efficacy of the Strengthening Spleen and Draining Dampness therapy was analyzed using repeated measures analysis of variance (ANOVA). Kaplan-Meier survival curves and multivariate proportional hazards model (Cox regression models) were employed to identify factors associated with treatment outcomes.
resultsA total of 265 patients were included, with a median follow-up duration of 96 months (36, 122). TCM treatment significantly reduced 24-h urinary protein levels (
conclusionThe Strengthening Spleen and Draining Dampness therapy demonstrated robust short- and long-term efficacy in treating IMN, with high rates of remission and renal survival over 10 years. Key factors influencing clinical remission included the duration of TCM treatment, baseline serum albumin levels, the presence of hypertension, and the rate of increase in serum albumin within the first year. These findings suggest that this TCM approach provides a viable long-term treatment option for IMN.
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