Evidence map›Paper›PMID 40810230›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Study on the mechanism of Fuzi Lizhong decoction in the treatment of colorectal cancer of spleen kidney deficiency from the perspective of intestinal flora and hypoxia inducible factor-1α signalling pathway.

Zhang Lina, Lin Xiu, Zhao Xin, L I Wenjuan, Zhao Ye

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in pharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhang LinaDepartment of Oncology, Ruikang Hospital Affiliated Guangxi University of Chinese Medicine, Nanning 530011, China.
Lin XiuDepartment of Surgery, Guilin University of Technology Hospital, Guilin 541004, China.
Zhao XinMedical Laboratory, the Second People's Hospital of Datong, Datong 037000, China.
L I WenjuanDepartment of Oncology, Ruikang Hospital Affiliated Guangxi University of Chinese Medicine, Nanning 530011, China.
Zhao YeDepartment of Public Health, International College, Krirk University, Bangkok 10220, Thailand.

Funding

Guangxi Natural Science Foundation "Controllable Synthesis of Ordered Mesoporous Seafoam-Loaded g-C3N4 Gomposites and Their Mechanism of Adsorption-Photocatalytic Degradation of Antidepressants in Water Bodies" 2017GXNSFBA198216Open Fund for the Director of Guangxi Key Laboratory of Spatial Information and Geographic Information "Geographic Spatial Analysis of Regional Urinary Tract Stone Disease" 19-185-10-04
6 · The paper itself

Abstract

objectiveTo evaluate the effect of Fuzi Lizhong decoction on intestinal flora, serum inflammatory factors, and hypoxia inducible factor-1α (HIF-1α) in patients with colorectal cancer associated with spleen and kidney

methodsA total of 100 patients diagnosed with advanced colorectal cancer were randomly divided into two groups: a control group (CON, 50) and a Traditional Chinese Medicine (TCM) group (

resultsAfter six weeks, the levels of Lactobacillus and Bifidobacterium were significantly higher, while the levels of Enterobacter and Enterococcus were significantly lower in the TCM group compared to the control group (

conclusionFuzi Lizhong decoction effectively improves intestinal microbiota composition, reduces inflammatory factors and HIF-1α expression, alleviates chemotherapy-related adverse reactions, enhances clinical efficacy, and may inhibit tumor growth in patients with colorectal cancer.

Indexed as

Colorectal NeoplasmsDrugs, Chinese HerbalGastrointestinal MicrobiomeHypoxia-Inducible Factor 1, alpha SubunitKidneySpleenAdultAgedFemaleHumansInterleukin-6MaleMiddle AgedSignal TransductionTumor Necrosis Factor-alphaVascular Endothelial Growth Factor ADrugs, Chinese HerbalHypoxia-Inducible Factor 1, alpha SubunitInterleukin-6Lizhong decoctionTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Acolorectal neoplasmsFuzi Lizhong decoctiongastrointestinal microbiomehypoxia-inducible factor 1, alpha subunitinterleukin-6tumor necrosis factor-alphavascular endothelial growth factors

Identifiers

PMID40810230
PMCPMC12340584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.