ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Mechanism of electroacupuncture involve in lens-induced myopia guinea pigs by inhibiting wnt/β-catenin signaling pathway.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Role of BDNF in form-deprivation myopia progression in guinea pigs.Frontiers in immunology · 2026Article
- Mechanism-Driven Translation of Electroacupuncture for Depression: Bridging the Gap Between Preclinical and Clinical Research.Neuropsychiatric disease and treatment · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo determine the mechanism of electro-acupuncture (EA) effect by the wingless-related integration site (Wnt)/β-catenin pathway in the guinea pig myopia model.
methodsFollowing myopia induction and EA, guinea pigs were treated with biometry to evaluate refraction and axial length. Hematoxylin and eosin (HE) staining was used to observe that the retina, choroid, and sclera had abnormal morphology. At 4, 6, and 8 weeks, quantitative polymerase chain reaction (qPCR) was used to identify the expression of matrix metallopeptidase-2 (MMP-2)/MMP-3/tissue inhibitor of metalloprotease-2 (TIMP-2)/TIMP-3/Wnt family member 2B (WNT2B)/WNT3A/ WNT7B/beta-catenin 1 (CTNNB1), and dickkopf wnt signaling pathway inhibitor 1 (DKK-1) mRNAs in the retina, choroid, and sclera. Western blot was used to detect the protein expression of WNT7B/2B/3A, CTNNB1 and DKK-1 in retina, choroid and sclera at 4 weeks. Enzyme-linked immunosorbent assay was used to detect the protein expression of MMP-2/TIMP-2 and MMP-3/TIMP-3 in serum at 4 weeks. Moreover, a DKK-1 inhibitor was injected into the vitreous cavity, and the expression of the above molecules was detected.
resultsEA could reduce the optic axial length and diopter and ameliorate ocular pathology, inhibited the expression of MMP-2/MMP-3 and WNT2B/WNT3A/ WNT7B/CTNNB1, while increased the expression levels of TIMP-2/TIMP-3 and DKK-1. However, the expression levels of WNT2B/WNT3A/WNT7B/CTNNB1 and MMP-2/MMP-3 were significantly increased, and the TIMP-2/TIMP-3 and DKK-1 expression levels were decreased after injected DKK-1 inhibitor.
conclusionThe mechanism of EA's effects on myopia may involve the downregulation of the Wnt/β-catenin pathway and correct MMP-2/MMP-3/TIMP-2/TIMP-3 balance.
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