Evidence map›Paper›PMID 40810223›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

An's anorectal fumigation lotion for nuclear factor kappa-B pathway-targeted treatment of inflammatory mixed hemorrhoids.

Feng Dayong, A N Ayue, Feng Yuening, Wang Chunhui, Bai Zhiyong, Wang Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Feng DayongDepartment of Anorectal surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
A N AyueDepartment of surgery, the 305th Hospital of the Chinese People's Liberation Army, Beijing 100017, China.
Feng YueningDepartment of Anorectal surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Wang ChunhuiDepartment of Anorectal surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Bai ZhiyongDepartment of Anorectal surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
Wang QianDepartment of Anorectal surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.

Funding

Science and Technology Innovation Project of the Chinese Academy of Traditional Chinese Medicine: Mechanism of An's Anorectal Fumigation Lotion in the Treatment of Inflammatory Mixed hemorrhoids based on Nuclear Factor Kappa-B Pathway CI2021A02104
6 · The paper itself

Abstract

objectiveTo investigate the mechanism by which An's anorectal fumigation lotion (AAFL) treats inflammatory mixed hemorrhoids.

methodsEighty Sprague-Dawley rats, with an equal number of males and females, were randomly assigned to the following four groups: control, model, AAFL, and positive groups. Following hemorrhoid induction, hemorrhoidal tissues were collected from the rats for analysis. Pathological alterations in these tissues were examined

resultsCompared with the control group, the rats in each treatment group showed general improvements in hemorrhoidal tissue pathology. The AAFL group showed increased IκB expression and decreased IL-1β, IL-6, TNF-α, NF-κB, p65, and IκK-β expressions.

conclusionAAFL can decrease the production of inflammatory markers by targeting the NF-κB pathway, resulting in improved pathological conditions in mixed hemorrhoids. Our findings will aid in the treatment of mixed hemorrhoids.

Indexed as

Drugs, Chinese HerbalHemorrhoidsNF-kappa BAnimalsFemaleHumansInterleukin-1betaInterleukin-6MaleRatsRats, Sprague-DawleySignal TransductionTumor Necrosis Factor-alphaDrugs, Chinese HerbalInterleukin-1betaInterleukin-6NF-kappa BTumor Necrosis Factor-alphaAn’s anorectal fumigation lotionhemorrhoidsinflammatory factorsNF-kapa B

Identifiers

PMID40810223
PMCPMC12340583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.