Evidence map›Paper›PMID 40810222›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Effect of Jiawei Huangqi Guizhi decoction on the expression of gastrin content and phosphatidylinositol 3-kinase/ protein kinase B/mechanistic target of rapamycin complex 2 signalling pathways in rats with chronic atrophic gastritis.

Zhou Xia, Liang Kaiqing, Chen Weigang, Cao Yong, Duo Hongdong, L I Qiangbin, A N Yun

Abstract read
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In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of mTORC2/RICTOR in immune cells and inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhou XiaDepartment of Gynecology and Internal Medicine, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, Chin.
Liang KaiqingPanyu Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Chen WeigangDepartment of Gynecology and Internal Medicine, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, Chin.
Cao YongCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Duo HongdongDepartment of Gynecology and Internal Medicine, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, Chin.
L I QiangbinDepartment of Gynecology and Internal Medicine, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, Chin.
A N YunDepartment of Gynecology and Internal Medicine, Panyu Hospital of Traditional Chinese Medicine, Guangzhou 511400, Chin.

Funding

Guangzhou Science and Technology Bureau Research Fund: the Mechanism of Action of Huangqi Guizhi Decoction on Precancerous Lesions in Cag Rats was Studied based on the Phosphatidylinositol 3-Kinase-Protein Kinase B-Mechanistic Target of Rapamycin Complex 2 Pathway 202102080643Guangzhou Traditional Chinese Medicine and Integrative Medicine Research Project: Observation on the Therapeutic Effect of Wenyang Jianpi Ointment on Chronic Atrophic Gastritis of Spleen and Stomach Weakness Type and Study on its Regulatory Effect on Transforming Growth Factor Beta 3 20222A010079Panyu District Science and Technology Project: the Mechanism by which the Modified Huangqi Guizhi Decoction Regulates the Transforming Growth Factor-β3 Signaling Pathway to Improve Precancerous Lesions in Rats with Chronic Atrophic Gastritis 2020-Z04-025
6 · The paper itself

Abstract

objectiveTo investigate the effects of Jiawei Huangqi Guizhi decoction on chronic atrophic gastritis (CAG) in rats and its modulation of the phosphatidylinositol 3-kinase/protein kinase B/ mechanistic target of rapamycin complex 2 (PI3K/Akt/ mTORC2) signaling pathway.

methodsCAG was induced in rats and treated with high-, medium-, or low-dose Jiawei Huangqi Guizhi decoction. Gastric histopathology was observed by hematoxylin and eosin staining. Serum levels of gastrin, PI3K, Akt, and mTORC2 were detected by enzyme-linked immunosorbent assay. Gene and protein expression levels were analyzed by reverse transcription polymerase chain reaction and western blot.

resultsThe decoction alleviated gastric mucosal injury, reduced inflammation, and restored epithelial structure. It regulated PI3K, Akt, and mTORC2 expression at both mRNA and protein levels.

conclusionJiawei Huangqi Guizhi decoction may prevent CAG progression by improving gastric tissue and modulating the PI3K/Akt/mTORC2 signaling pathway.

Indexed as

Drugs, Chinese HerbalGastrinsGastritis, AtrophicMechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsChronic DiseaseHumansMaleRatsRats, Sprague-DawleySignal TransductionDrugs, Chinese HerbalGastrinshuangqi decoctionMechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAktgastrinsJiawei Huangqi Guizhi decoctionmechanistic target of rapamycin complex 2pathologyPI3Ksignal transduction

Identifiers

PMID40810222
PMCPMC12340592

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.