Evidence map›Paper›PMID 40810219›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Qigu capsule alleviates dexamethasone-induced muscle dysfunction through mitochondrial biogenesis.

Shi Jinyu, G E Haiya, Yang Zongrui, Zhan Hongsheng

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Shi JinyuShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
G E HaiyaShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
Yang ZongruiShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
Zhan HongshengShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.

Funding

"Extension Plan for the Inheritance of Shanghai Style Traditional Chinese Medicine Schools", "Construction of TCM Specialty Alliance for Muscle and Bone Injury in East China Region and City Level"(ZY 2021-2023)-0302Program for Shanghai High-Level Local University Innovation Team SZY20220315Second Round of Construction Project of National TCM Academic School Inheritance Studio "Shi's Trauma Department"(Letter of the People's Education of Traditional Chinese Medicine 2019) No. 62Shanghai Clinical Research Center for Chronic Musculoskeletal Diseases 20MC1920600Shanghai High-level Local Universities "Chronic Muscle and Bone Damage Research and Transformation" Innovation Team(No. 3 of Shanghai Education Commission 2022)Shanghai Key Clinical Specialty "Traditional Chinese Medicine Orthopaedic Traumatology" shslczdzk03901Shanghai Shenkang Hospital Development Center Clinical Three-year Action Plan SHDC2020CR3090B
6 · The paper itself

Abstract

objectiveTo explore the potential molecular mechanism of Qigu capsule (，QGC) improve the functional performance of skeletal muscle.

methodsThe primary components of QGC were analyzed using high-performance liquid chromatography (HPLC). Muscle dysfunction was established in male C57BL/6 mice treated with dexamethasone (1 mg/kg body weight, i.p., six weeks). Rotarod test, mitochondrial ultrastructure, respiratory chain complex V activity, succinate dehydrogenase (SDH) activity, adenosine triphosphate (ATP) content, and reactive oxygen species (ROS) levels were assessed. The mitochondrial biogenesis-related protein expressions were analyzed using Western blot or polymerase chain reaction (PCR).

resultsQGC treatment enhanced Rotarod test performance. Additionally, QGC significantly alleviated dexamethasone-induced mitochondrial damage, reduced mitochondrial swelling, increased respiratory chain complex enzyme activity, SDH activity, ATP content, and decreased ROS levels. PCR and western blot results revealed that QGC enhanced mitochondrial biogenesis

conclusionsQGC ameliorates dexamethasone-induced skeletal muscle dysfunction by activating AMPK/ PGC-1α, which might be developed as a therapeutic agent for treating age-related muscle weakness.

Indexed as

DexamethasoneDrugs, Chinese HerbalMitochondriaMuscle, SkeletalMuscular DiseasesOrganelle BiogenesisAdenosine TriphosphateAMP-Activated Protein KinasesAnimalsCapsulesHumansMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReactive Oxygen SpeciesAdenosine TriphosphateAMP-Activated Protein KinasesCapsulesDexamethasoneDrugs, Chinese HerbalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReactive Oxygen SpeciesAMP-activated protein kinasesmuscle weaknessorganelle biogenesisperoxisome proliferator-activated receptor gamma coactivator 1-alphaQigu capsulesarcopenia

Identifiers

PMID40810219
PMCPMC12340593

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.