Evidence map›Paper›PMID 40810160›Full record

ArticleACS pharmacology & translational science2025

Antineuroblastoma Activity Evaluation and Mechanism of Novel PD-L1 Small Molecule Inhibitors through Immune and Non-Immune Pathways.

Jianwei Wang, Yongnan Zhou, Zejie Chen, Xiaoyin Zhao, Haoran Xu, Feng Zhang, Awadasseid Annoor, Rui Wang, Caiyun Wu, Hua Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jianwei WangLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Yongnan ZhouLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Zejie ChenLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Xiaoyin ZhaoLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Haoran XuLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Feng ZhangLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Awadasseid AnnoorKecheng Industrial Development Institute, Zhejiang University of Technology, Quzhou 324000, China.
Rui WangLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Caiyun WuLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Hua ZhangLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Mengyu ZhuLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.
Wen ZhangLab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, Quzhou, Deqing 313299, China.ORCID https://orcid.org/0000-0002-3247-9672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is a pediatric solid tumor originating in the sympathetic nervous system, primarily affecting children under 10 years old. Metastatic, high-risk NB often exhibits elevated PD-L1 expression, which is linked to poor prognosis. In this study, we screened 41 newly synthesized biphenyl small molecules for activity against PD-L1 highly expressed NB cell lines. Compound

Indexed as

immune checkpoint inhibitorMAPK pathwayneuroblastomaPD-L1SK-N-SH NOG mouse modelsmall molecules

Identifiers

PMID40810160
PMCPMC12340650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.