Evidence map›Paper›PMID 40810157›Full record

ArticleACS pharmacology & translational science2025

Mechanically Active and Antimicrobial Wound Closure Using an Adhesive Hydrogel-Elastomer.

Cynthia Liu, Bersa Kelkai, David Wu, Alexander Tatara, Juan Cintron, David J Mooney, Benjamin R Freedman

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cynthia LiuHarvard Medical School, Boston, Massachusetts 02115, United States.
Bersa KelkaiHarvard Medical School, Boston, Massachusetts 02115, United States.
David WuJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Alexander TataraJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.
Juan CintronMassachusetts Institute of Technology, Boston, Massachusetts 02139, United States.
David J MooneyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.ORCID https://orcid.org/0000-0001-6299-1194
Benjamin R FreedmanHarvard Medical School, Boston, Massachusetts 02115, United States.ORCID https://orcid.org/0000-0001-9406-773X

Funding

Supplement Multifunctional Tough Adhesive Hydrogels to Recruit, Expand, and Deliver Tendon Cells During Aging and InjuryR00AG065495 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Benjamin Ross Freedman · 2023 to 2026
$842k
NIA NIH HHS R00 AG065495
6 · The paper itself

Abstract

Chronic wounds affect millions worldwide and lead to pain, infection, and impaired quality of life. Current wound sealing technologies for chronic wound care remain largely palliative, with poor adhesion, weak mechanical properties, and limited ability to deliver therapeutics. Emerging technologies, including autologous blood products, growth factor-enhanced scaffolds, and artificial skin, although clinically successful, are limited from widespread adoption by the high cost of production and challenging clinical workflow. Here, we present a tough adhesive-elastomer wound care technology that is mechanically robust to approximate wound edges, can adhere strongly to wet and dynamic wound surfaces, is capable of delivering antimicrobials, and supports cell migration and proliferation. This technology has the potential to address an unmet clinical need in wound healing.

Indexed as

antimicrobialbiomaterialsmechanobiologyregenerative medicinetissue adhesiveswound healing

Identifiers

PMID40810157
PMCPMC12340631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.