Evidence map›Paper›PMID 40810147›Full record

ArticleACS pharmacology & translational science2025

Development and Mechanistic Evaluation of a Lithocholic Acid Derivative as an Environmentally Safe Rodenticide.

Kana Okamura, Kazuki Takeda, Satoru Nagaoka, Chiharu Ogura, Misaki Fukamatsu, Mayumi Degawa, Hiroyuki Kagechika, Kenji Ohgane, Ryo Kamata, Aya Tanatani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kana OkamuraDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Kazuki TakedaLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, East 23-5-35, Towada-shi, Aomori 0340021, Japan.ORCID https://orcid.org/0000-0002-3265-4143
Satoru NagaokaDaimaru Compound Chemical Co. Ltd, 6320-1 Toyosaka, Matsushiromachi, Nagano-shi, Nagano 3811222, Japan.
Chiharu OguraDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.
Misaki FukamatsuLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, East 23-5-35, Towada-shi, Aomori 0340021, Japan.
Mayumi DegawaDaimaru Compound Chemical Co. Ltd, 6320-1 Toyosaka, Matsushiromachi, Nagano-shi, Nagano 3811222, Japan.
Hiroyuki KagechikaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.ORCID https://orcid.org/0000-0002-6747-1013
Kenji OhganeDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.ORCID https://orcid.org/0000-0003-0565-6503
Ryo KamataLaboratory of Toxicology, School of Veterinary Medicine, Kitasato University, East 23-5-35, Towada-shi, Aomori 0340021, Japan.
Aya TanataniDepartment of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.ORCID https://orcid.org/0000-0002-6667-8506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Control of rodents remains a critical global challenge due to their role in spreading zoonotic diseases and damaging ecosystems, but current rodenticides, such as anticoagulant rodenticides, have significant limitations, including the development of resistance in rodents and bioaccumulation leading to secondary toxicity in nontarget species. Dcha-20, a lithocholic acid derivative and vitamin D receptor agonist, was synthesized to potentially address these issues. This study investigates its rodenticidal efficacy, safety profile, and mechanism of action. The oral LD

Indexed as

mode of actionpharmacokineticsrodenticidetoxicityvitamin D

Identifiers

PMID40810147
PMCPMC12340632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.