ArticleACS pharmacology & translational science2025
Discovery of Bisindoles that Activate Tumor-Associated Macrophages and Enhance Antitumor Immunity.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The clinical successes in immunotherapy have been staggering but remain partially unsatisfactory. Small molecules may play an important role individually or in combination with antibiotics in this field. Therefore, the aim of this work is to identify small molecules that potentiate antitumor immunity. A natural product library was screened by using a macrophage M2-like polarization model. A series of bisindoles (CX-1-5) exhibited inhibitory effects on macrophage M2-like polarization. CX-1 inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins.
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