Evidence map›Paper›PMID 40810058›Full record

ArticleProceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences2025

Leveraging virtual reality to improve medication adherence among marginalized populations with high-risk chronic health conditions: Proof-of-concept protocol, considerations, and next steps.

Tiffany R Glynn, Roger D Dias, Robson J Verly, Conall O'Cleirigh, Peter R Chai

Abstract read
In one paragraph

Article in Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tiffany R GlynnHarvard Medical School, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA.
Roger D DiasHarvard Medical School, Brigham and Women's Hospital, Boston, MA.
Robson J VerlyHarvard Medical School, Brigham and Women's Hospital, Boston, MA.
Conall O'CleirighHarvard Medical School, Massachusetts General Hospital, Boston, MA.
Peter R ChaiHarvard Medical School, Brigham and Women's Hospital, Boston, MA.

Funding

PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorderDP2DA056107 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2022 to 2022
$2.7M
Leveraging mHealth to develop syndemic-based behavioral medicine HIV prevention for the emergency department to reach people who use drugsK23DA060719 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI Tiffany Rose Glynn · 2024 to 2026
$599k
NIAID NIH HHS T32 AI007433NIDA NIH HHS DP2 DA056107NIDA NIH HHS K23 DA060719NIDA NIH HHS L60 DA059128
6 · The paper itself

Abstract

Marginalized populations experience high prevalence of chronic health conditions - many of which require optimal medication adherence to avoid significant consequences for mortality and morbidity. Yet, marginalization and its complex sequelae create barriers for adherence and access to care, creating a cycle of health inequity. Individuals are not fully benefiting from evidence-based behavioral adherence interventions, like "Life-steps", potentially due to lack of embedded experiential learning, which is key for individuals experiencing complex barriers to medication adherence. Leveraging interactive artificial intelligence technologies through immersive virtual reality is a promising avenue to bolster behavioral adherence interventions. We present our current proof-of-concept work for "Life-steps VR", an integration of such technologies into the empiric behavioral medication adherence intervention. We then discuss our next steps for further refinement and testing of the technology with consideration for equity, democratization, and accessibility of health technologies. We conclude with a discussion of future potential iterations of Life-steps VR.

Indexed as

artificial intelligencebehavioral interventionchronic health conditionsmedication adherencevirtual reality

Identifiers

PMID40810058
PMCPMC12341852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.