ArticleToxicology reports2025
Antioxidant activity and acute toxicity of ziziphus abyssinica extracts: A comparative study of root and leaf extracts.
Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
Ziziphus abyssinica Hochst. ex A. Rich., a traditionally valued Ethiopian medicinal plant, was investigated for its phytochemical composition, antioxidant potential, and acute toxicity to validate its ethnopharmacological uses. Through sequential solvent extraction (n-hexane to aqueous), methanol and ethyl acetate fractions of leaves exhibited superior antioxidant activity (DPPH EC50: 12.5 ± 0.8 μg/mL; ABTS EC50: 15.2 ± 1.0 μg/mL), correlating with high phenolic (120.5 ± 0.7 mg GAE/g) and flavonoid (85.6 ± 0.6 mg QE/g) content. Leaves consistently outperformed roots across assays, reflecting tissue-specific metabolic specialization. Comprehensive phytochemical profiling revealed alkaloids, saponins, and glycosides, with quantitative analysis demonstrating solvent-dependent metabolite recovery. Acute toxicity testing using Organization for Economic Co-operation and Development (OECD) Guideline 425, at 2000 mg/kg showed no mortality or significant biochemical alterations, though mild hepatic vacuolization was observed histologically. The study highlights Z. abyssinica's dual promise as a source of natural antioxidants with a favorable safety profile, while establishing standardized protocols for its evaluation. These findings bridge traditional knowledge with scientific validation, supporting its potential development for nutraceutical or therapeutic applications targeting oxidative stress-related pathologies.
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