Mild and reversible nephrotoxicity following repeated administration of damnacanthal in nude mice.

Noppanan Kotsaouppara, Thunyatorn Yimsoo, Worapapar Treesuppharat, Jeeraphong Thanongsaksrikul, Potjanee Srimanote

Abstract read

In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Antitumor Activity of the Ethanolic Extract fromPharmaceutics · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noppanan KotsaoupparaGraduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani 12120, Thailand.

Thunyatorn YimsooLaboratory Animal Center, Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.

Worapapar TreesuppharatThammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, Thailand.

Jeeraphong ThanongsaksrikulGraduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani 12120, Thailand.

Potjanee SrimanoteGraduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani 12120, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Damnacanthal was previously shown to be a promising colorectal cancer therapeutic candidate. Its efficacy relied on multiple administrations. This study, therefore, aims to assess the renal toxicity of 20 mg/kg damnacanthal (DAM20) in nude mice following three, seven and 14 repeated administrations. No clinical signs of renal toxicity and abnormal renal tissue histopathology were demonstrated. Seven repeated doses of DAM20 resulted in a decrease in BUN, increased urine-serum creatinine ratio, and urine microalbumin leakage (

Indexed as

Caspase-3 activationChronic kidney diseaseColorectal cancer therapeutic candidateDamnacanthalNephrotoxicityPreclinical researchRenal injury

Identifiers

PMID40810007

DOI10.1016/j.toxrep.2025.102088

PMCPMC12345006

What OpenQuestion holds

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LicenceCC BY-NC

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.