ArticleBiomedical optics express2025
Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Enhancement of Cerebral Oxygenation by Lower-Limb Neuromuscular Electrical Stimulation in Stroke Survivors.Annals of biomedical engineering · 2026Observational
- Impact of the β correction factor on the accuracy of speckle contrast imaging measurements.Biomedical optics express · 2026Article
- Optical methods for cuffless blood pressure measurements.Biophotonics discovery · 2026Review
- Synthetic-data-driven LSTM framework for tracing cardiac pulsation in optical signals.Biomedical optics express · 2025Article
- Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations.Biomedical optics express · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
This work introduces high-speed (390 Hz) speckle contrast optical spectroscopy (SCOS) to enable simultaneous measurements of multi-anatomic site microvascular blood volume and flow oscillations. Simultaneous blood flow and volume waveforms were extracted at two wavelengths on the wrist and finger, in reflectance and transmission mode, respectively. Blood volume changes (also known as photoplethysmography, or PPG) were determined based on intensity oscillations. Blood flow information was determined based on dynamic light scattering information encoded in the 2D spatial speckle pattern after removal of stochastic and instrument noise. We extracted a wide array of temporal, shape-based, and frequency-domain features from each high-resolution waveform, as well as features that characterize the temporal relationships between these features. These features and their inter-relationships are determined by the dynamic biomechanical properties of peripheral microvasculature, including vascular compliance and resistance, which are key determinants of dynamic changes in systemic blood pressure (BP). In comparison to PPG alone, SCOS demonstrated a notable 31% improvement (p = 3.45 * 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.