ArticleBiomedical optics express2025
Optoretinography with actively stabilized adaptive optics optical coherence tomography.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Split-spectrum amplitude decorrelation optoretinography for functional imaging of mouse photoreceptors.Biomedical optics express · 2026Article
- Phase-based optoretinographic measurements of cones with a raster-scanning adaptive optics OCT are highly repeatable.Biomedical optics express · 2026Article
- Dark adaptation of cone photoreceptor responses is revealed by optoretinography.bioRxiv : the preprint server for biology · 2026Article
- Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.Biomedical optics express · 2026Article
- Imaging of Tissue and Cell Dynamics: introduction to the feature issue.Biomedical optics express · 2026Article
- Interferometric imaging of the reversible rhodopsin dynamics in the living rat eye.Nature communications · 2025Article
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Optoretinography (ORG) is the optical measurement of changes in the retina in response to light stimulation. Adaptive optics optical coherence tomography (AOOCT) records photoreceptor ORGs by measuring the physical changes in their outer segment lengths in response to light stimulation. The main difficulty in recording these nanometer-scale changes is constant eye motion. Typically, fast volume acquisitions are used with offline spatial registration to compensate for the effect of eye motion. Here, we present an alternate solution whereby an adaptive optics scanning light ophthalmoscope (AOSLO) is used to measure the eye motion and actively guide the AOOCT beam to compensate for eye motion in real time. This system's cellular-scale tracking offers unparalleled control over scanning raster size and shape, allowing for high-speed (up to 100 kHz) ORG acquisition from targeted locations. We validate the method by comparing cone classifications against those made with an established ORG approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.