ArticleBiomedical optics express2025
Wide-field choriocapillaris mapping with 3.4 MHz adaptive optics-optical coherence tomography angiography.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Impact of Swept-Source OCT Angiographic Scanning Speeds on the Detection of Choriocapillaris Flow Deficits in Eyes With AMD.Translational vision science & technology · 2026Article
- Optical coherence tomography angiography reveals structural and hemodynamic remodeling of cerebral penetrating vessels owing to aging.Biomedical optics express · 2026Article
- Article
- Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025Article
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Authors and funding
2 authors.
Funding
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Abstract
The human choriocapillaris (CC) plays an essential role in supporting the overlying photoreceptor and retinal pigment epithelial cells and in maintaining overall retinal health. Disruption of CC structure and function is implicated in many retinal diseases, including age-related macular degeneration. Despite recent advances in ophthalmic imaging technologies, a full understanding of disease mechanisms remains elusive due to the inability to visualize CC microstructure. Here, we present a 3.4 MHz adaptive optics-optical coherence tomography angiography (AO-OCTA) approach for mapping the human choriocapillaris at high resolution to address the primary limitations of existing methodologies for CC imaging. We optimized our AO-OCTA acquisition protocols and offered guidelines for performing AO-OCTA for vessel imaging. Our approach achieves high resolution and high contrast CC imaging with single volume acquisition that takes <1 second, allowing rapid montaging and quantification over a 34° field of view. The proposed AO-OCTA method offers a more complete view of the outer retinal neurovascular complex, opening tremendous opportunities to investigate chorioretinal diseases.
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Registered trials
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