Evidence map›Paper›PMID 40809963›Full record

ArticleBiomedical optics express2025

Three-dimensional dynamic optical coherence tomography for breast tumor margin assessment.

Joel A Bellesini, Ken Y Foo, Jiayue Li, Rowan W Sanderson, Renate Zilkens, Laura Gale, Mireille Hardie, Saud Hamza, Anmol Rijhumal, Christobel M Saunders and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joel A BellesiniBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.ORCID https://orcid.org/0000-0002-2628-1563
Ken Y FooBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.ORCID https://orcid.org/0000-0002-5984-2574
Jiayue LiBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.
Rowan W SandersonBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.ORCID https://orcid.org/0000-0002-8877-7847
Renate ZilkensBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.
Laura GaleDivision of Surgery, Medical School, The University of Western Australia, Crawley, WA 6009, Australia.
Mireille HardieDivision of Surgery, Medical School, The University of Western Australia, Crawley, WA 6009, Australia.
Saud HamzaBreast Centre, Fiona Stanley Hospital, Murdoch, WA 6150, Australia.
Anmol RijhumalDivision of Surgery, Medical School, The University of Western Australia, Crawley, WA 6009, Australia.
Christobel M SaundersMedical School, The University of Western Australia, Crawley, WA 6009, Australia.
Brendan F KennedyBRITElab, Harry Perkins Institute of Medical Research, Nedlands and Centre for Medical Research, The University of Western Australia, Crawley, WA 6009, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraoperative margin assessment techniques are needed to reduce the re-excision rate in breast-conserving surgery. Optical coherence tomography (OCT) is a non-invasive imaging technique capable of rapid three-dimensional (3-D) imaging of the internal microstructure of tissues. However, there is often low contrast between morphological features in breast tissue. Dynamic OCT (d-OCT), which provides additional contrast derived from the temporal variance of the OCT signal caused by intrinsic motion within the tissue, may provide a solution. However, few studies have applied it to breast tumor margin assessment. In this study, we acquired 3-D d-OCT images of ten human mastectomy specimens and three wide local excisions from breast-conserving surgery (BCS) procedures and, in each case, performed co-registered histology for validation. To optimize the trade-off between spatial resolution, temporal resolution, and acquisition time, we considered a range of acquisition settings. Several methods for visualizing d-OCT images were investigated, including Fourier weighted mean frequency, Fourier power spectral analysis, using red-green-blue (RGB) and hue-saturation-value (HSV) color spaces, and phase variance. We present d-OCT images of invasive ductal carcinoma (IDC), ductal carcinoma

Identifiers

PMID40809963
PMCPMC12339312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.