Evidence map›Paper›PMID 40809942›Full record

ArticleComputers & chemical engineering2025

Systematic design of pulse dosing to eradicate persister bacteria: The case of fluoroquinolones.

Garima Singh, Sayed Golam Mohiuddin, Sreyashi Ghosh, Jenet Narzary, Mehmet A Orman, Michael Nikolaou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computers & chemical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Garima SinghChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.ORCID 0000-0002-8207-7532
Sayed Golam MohiuddinChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.
Sreyashi GhoshChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.ORCID 0000-0002-0346-7381
Jenet NarzaryChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.ORCID 0009-0009-5101-8044
Mehmet A OrmanChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.
Michael NikolaouChemical and Biomolecular Engineering Department, University of Houston, Houston, TX, USA.ORCID 0000-0003-0241-6600

Funding

Personalized Antimicrobial Combinations to Combat ResistanceR01AI140287 · NIAID · UNIVERSITY OF HOUSTON · PI VINCENT H TAM · 2018 to 2026
$5.9M
Characterizing a Self-Digesting-Mediated Reversible Drug Tolerance Mechanism in BacteriaR01AI143643 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2020 to 2024
$1.9M
NIAID NIH HHS R01 AI140287NIAID NIH HHS R01 AI143643
6 · The paper itself

Abstract

A small fraction of infectious bacteria use persistence as a strategy to survive exposure to antibiotics. Pulse dosing of antibiotics, if designed well, has long been considered a potentially effective strategy towards eradication of such bacterial pathogens. In a recent study, we developed a method to systematically design optimal pulse dosing regimens for rapid eradication of persisters with

Indexed as

FluoroquinolonesModelingPersister cellsPulse dosing

Identifiers

PMID40809942
PMCPMC12347520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.