Evidence map›Paper›PMID 40809932›Full record

Observational studyWorld journal of gastroenterology2025

Poor sleep and hepatic steatosis contribute to poorer quality of life in people with human immunodeficiency virus.

Ana N Hyatt, Sai K Kuchana, Eduardo Vilar-Gomez, Richard K Sterling, Susanna Naggie, Sonya L Heath, Jennifer C Price, Laura A Wilson, Holly Crandall, Samer Gawrieh and 5 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ana N HyattDepartment of Medicine, Division of Infectious Diseases, UTHealth Houston, Houston, TX 77030, United States. ana.n.hyatt@uth.tmc.edu.
Sai K KuchanaDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Eduardo Vilar-GomezDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Richard K SterlingDivision of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, VA 23219, United States.
Susanna NaggieDepartment of Internal Medicine, School of Medicine, Clinical Research Institute, Duke University, Durham, NC 27708, United States.
Sonya L HeathDepartment of Internal Medicine, University of Alabama at Birmingham Medical Center, Birmingham, AL 35233, United States.
Jennifer C PriceDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, CA 94143, United States.
Laura A WilsonDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, United States.
Holly CrandallDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Samer GawriehDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Naga ChalasaniDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Rohit LoombaDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, United States.
Mark S SulkowskiDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, United States.
Archita P DesaiDepartment of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Jordan E LakeDepartment of Medicine, Division of Infectious Diseases, UTHealth Houston, Houston, TX 77030, United States.

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
The Intersection of Personalized Medicine and Implementation Science to Improve Healthcare Utilization in CirrhosisK23DK123408 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DESAI, ARCHITA P. · 2020 to 2024
$903k
NIDDK NIH HHS K23 DK123408NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

backgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) and poor sleep are common among people with human immunodeficiency virus (PWH) and may mediate the impaired health-related quality of life (HRQoL) seen in PWH and in people with MASLD. However, the prevalence and burden of poor sleep in PWH and MASLD is not well described.

aimTo study the prevalence and multi-faceted relationship between MASLD, poor sleep, and HRQoL in PWH.

methodsIn this cross-sectional, observational study, adult PWH and no other known cause of liver disease underwent controlled attenuated parameter (for hepatic fat) and liver stiffness measurement

resultsPWH (

conclusionIn this cohort of PWH, there was no association between MASLD and sleep quality. Poor sleep, MASLD and liver fibrosis were independently associated with poor HRQoL.

Indexed as

Fatty LiverHIV InfectionsQuality of LifeSleep Wake DisordersAdultAgedCross-Sectional StudiesElasticity Imaging TechniquesFemaleHumansLiverMaleMiddle AgedPrevalenceSleep QualityUnited StatesHealth-related quality of lifeHuman immunodeficiency virusLiver fibrosisMetabolic dysfunction-associated steatotic liver diseaseSleep disorders

Identifiers

PMID40809932
PMCPMC12344371

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.