ArticleNutrition research and practice2025
The association between iodine intake and thyroid disease in iodine-replete regions: the Korean Genome and Epidemiology Study.
Article in Nutrition research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Iodine Intake and Risk of Mortality: Evidence from a Nationally Representative Korean Cohort.Nutrients · 2025Article
- Analysis and Risk Assessment of Total Iodine Content in Edible Seaweeds in South Korea.Foods (Basel, Switzerland) · 2025Article
- Nutrition and Micronutrient Interactions in Autoimmune Thyroid Disorders: Implications for Cardiovascular Health.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
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Authors and funding
4 authors.
Funding
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Abstract
BACKGROUND/
objectivesThe Korean population traditionally consumes more iodine-rich seaweeds than Western populations due to dietary culture and geographical location. However, the association between excessive iodine intake and thyroid disease remains controversial. This study aimed to evaluate the association between iodine intake and thyroid disease using the largest-scale Korean cohort data. SUBJECTS/
methodsThis study utilized data from 190,524 participants in the Korean Genome and Epidemiology Study. Iodine intakes were assessed using a validated semi-quantitative food frequency questionnaire. Iodine intake was classified into quintiles, and the association between iodine intake and the prevalence of thyroid disease was evaluated using multivariate logistic regression analysis.
resultsOf the 190,524 participants, 8,387 (4.40%) were diagnosed with thyroid diseases by a physician. In the total population, higher iodine intake was not associated with an increased risk of thyroid disease after adjusting for confounding variables. Additionally, the odds ratio for the highest iodine intake group compared to the lowest iodine intake group was 0.89 (95% confidence interval [CI], 0.71-1.11;
conclusionExcessive iodine consumption was not associated with thyroid disease in Korean adults. Further longitudinal studies are required to assess the long-term effects of iodine intake on thyroid disease.
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