Evidence map›Paper›PMID 40809868›Full record

ArticleBiology methods & protocols2025

Innovative approach for the qualitative-quantitative assessment of neurodevelopment biomarkers research in placenta tissue using immunohistochemistry digital image analysis.

Caroline Camilo, Luana Martos Vieira, Gisele Rodrigues Gouveia, Arleti Caramori Torrezan, Andrea Peixoto, Veronica Euclydes, Rossana Pulcineli Vieira Francisco, Alexandra Brentani, Aloisio Felipe-Silva, Helena Brentani

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Article in Biology methods & protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caroline CamiloDepartamento & Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403010, Brazil.ORCID https://orcid.org/0000-0001-7183-7754
Luana Martos VieiraDepartamento de Pediatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-000, Brazil.
Gisele Rodrigues GouveiaDepartamento & Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403010, Brazil.
Arleti Caramori TorrezanServiço de Anatomia Patológica, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil.
Andrea PeixotoServiço de Anatomia Patológica, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil.
Veronica EuclydesDepartamento & Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403010, Brazil.
Rossana Pulcineli Vieira FranciscoDepartamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-900, Brazil.
Alexandra BrentaniDepartamento de Pediatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403-000, Brazil.
Aloisio Felipe-SilvaServiço de Anatomia Patológica, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo 05508-000, Brazil.
Helena BrentaniDepartamento & Instituto de Psiquiatria, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 05403010, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to develop and validate a standardized, qualitative-quantitative protocol for digital IHC analysis to assess neurodevelopmental biomarkers in placental tissue. Placental tissues from 60 births were obtained from the Western Region Birth Cohort (ROC), and IHC staining was performed using Novolink

Indexed as

digital analysisimmunohistochemistryneurodevelopment biomarkersplacentaprotein expressionprotocol

Identifiers

PMID40809868
PMCPMC12349919

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.