Evidence map›Paper›PMID 40809846›Full record

ReviewFrontiers in genetics2025

X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome.

Kathryn Step, Thiago Peixoto Leal, Walaa A Kamel, Emily Waldo, Soraya Bardien, Ignacio F Mata

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kathryn StepDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Thiago Peixoto LealGenomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Walaa A KamelDepartment of Neurology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Emily WaldoGenomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.
Soraya BardienDivision of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Ignacio F MataGenomic Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X chromosome-wide association studies (XWAS) have identified susceptibility variants for various neurodegenerative and neurodevelopmental diseases. The unique characteristics of the chromosome require more complex analytical approaches than standard genome-wide association studies. Over the past 2 decades, refined XWAS methods have better accounted for this biology. Given that many neurological diseases show sex-biased prevalence, XWAS offers a valuable framework for investigating sex-specific genetic contributions. This review summarizes published neurological XWAS (

Indexed as

association analysisneurodegenerative diseaseParkinson’s diseasesex biassusceptibility variantsX-chromosome-wide association studyXWAS

Identifiers

PMID40809846
PMCPMC12343220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.