Evidence map›Paper›PMID 40809839›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2025

Epidemiological Study of Childhood Idiopathic Epilepsy from 1990 to 2021 at Global, Regional, and National Scales.

Li Wang, Lei Tang, Ji Zhang, Ye Li, Feng Zhang, Qiaoling Tang, Siyuan Ma, Ran Liu, Xiangbin Zhang, Sai Wang and 10 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Li WangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Lei TangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Ji ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Ye LiDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Feng ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Qiaoling TangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Siyuan MaDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Ran LiuDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Xiangbin ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Sai WangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Yupeng ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Lei ChenDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Junyi MaDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Xuelun ZouDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Tianxing YaoDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Rongmei TangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Yexiang YiDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.
Yi ZengDepartment of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, China.
Duolao WangDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom.
Le ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi, Nanchang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To address the long-term impact of childhood idiopathic epilepsy on health and families, and to provide epidemiological evidence for developing effective prevention and treatment strategies, this study aimed to explore the trends in incidence, deaths, and disability-adjusted life years (DALYs) of childhood idiopathic epilepsy globally and across regions from 1990 to 2021. Patients and Methods: This cross-sectional analysis utilized data from the 2021 Global Burden of Disease database, covering idiopathic epilepsy cases among children aged 0-14 years across 204 countries and regions. The study period was from September 15, 2024, to October 31, 2024. Key indicators included incidence, deaths (all-cause and specific), and DALYs, with trend analysis conducted using the exponential annual percentage change (EAPC). All analyses were stratified by region, country, gender, and sociodemographic index (SDI). Results: In 2021, there were 1,227,191 new cases of childhood idiopathic epilepsy globally (95% uncertainty interval [UI], 786,363-1,734,488). From 1990 to 2021, the total number of cases increased by 26.3% (95% UI, 6.8%-51.2%), with the incidence rising from 55.85 per 100,000 population to 60.998, and an EAPC of 0.2% (95% CI, 0.17-0.23). Deaths decreased by 29.5%, from 25,768 to 18,171, with the death rate dropping from 1.482 per 100,000 to 0.903 and an EAPC of -1.39% (95% CI, -1.48 to -1.3). DALYs decreased by 14.90%, reaching 3,564,497 in 2021 (95% UI, 2,700,944-4,753,410), with an EAPC of -0.94% (95% CI, -1.0 to -0.89). Low SDI regions bore the highest burden, with the highest death rate (1.459 per 100,000 in 2021). Regionally, tropical Latin America saw the fastest growth in incidence (EAPC 0.29), whereas Tajikistan had the highest death rate (2.766 per 100,000), and Taiwan Province of China had the highest DALY rate (99.718 per 100,000). Conclusion: Childhood idiopathic epilepsy remains a significant global health challenge, with an increasing incidence. Despite a decline in global deaths and DALYs, the disease burden in low SDI regions remains substantial. Understanding the epidemiological characteristics of childhood idiopathic epilepsy is critical for developing effective prevention and management strategies. The findings highlight the importance of targeted interventions in resource-limited settings to bridge the gap in treatment outcomes for childhood epilepsy globally.

Identifiers

PMID40809839
PMCPMC12348364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.