ArticleCureus2025
The Evolving Field of Regenerative Aesthetics: A Review and Case Series.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Integrative Aesthetics: Shaping the Emerging Frontier of Modern Aesthetic Medicine.Clinical, cosmetic and investigational dermatology · 2026Review
- Regeneration in Aesthetic Medicine: Mechanisms, Evidence, and Clinical Boundaries.Journal of cosmetic dermatology · 2026Review
- Facial Overfilled Syndrome: A Narrative Clinical Review.Clinical, cosmetic and investigational dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermal fillers such as calcium hydroxyapatite-carboxymethylcellulose (CaHA-CMC), polycaprolactone (PCL), and poly-l-lactic acid (PLLA) are increasingly used as 'biostimulators' to stimulate native collagen production for longer-lasting aesthetic improvement. Volume replacement should, ideally, renew local tissue architectures and functions, but the replaced volume may not align structurally or functionally with the original tissue. The ability to achieve this regenerative, biostimulatory aesthetic rejuvenation requires a thorough understanding of the principles and mechanisms of tissue regeneration and its proper application. We reviewed the concepts of regenerative medicine, regenerative aesthetics, and biostimulation in the context of PLLA and CaHA and discussed the effects on immunological pathways and neocollagenesis when these materials are used as biostimulators in clinical aesthetics. Additionally, to understand how the concept of regenerative aesthetics is applied in the real world, we present cases demonstrating best practices and outcomes when using CaHA-CMC in a group of 11 Asian patients. Asian physicians' practices with CaHA-CMC have evolved beyond its volumizing and contouring benefits to its ability to induce regeneration in aging tissues. This has been achieved through the use of CaHA-CMC as monotherapy or in combination with other modalities. Moreover, CaHA-CMC allows physicians to offer a single, minimally invasive product to patients seeking treatment for skin laxity, wrinkles, crepiness, and volume loss while achieving multiple visible aesthetic improvements. Unlike conventional dermal fillers, the ability to leverage the regenerative qualities of CaHA-CMC effectively resolves age-related aesthetic issues in a durable manner using their body's own systems, allowing patients to emphasize their own unique features.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.