ArticleCureus2025
Histopathological Analysis of Myocardial Remodeling Following Heart Failure: A Cadaveric Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Impact of a durable left ventricular assist device on inflammation and cardiac remodelling in subjects with advanced heart failure.Open heart · 2026Observational
- Angiotensin II-driven coronary vasculopathy and pressure-overload myocardial remodeling represent distinct vascular phenotypes.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease and aging are key contributors to myocardial remodeling, often leading to fibrosis, cellular hypertrophy, and impaired cardiac function. Understanding these structural changes is essential for explaining the pathophysiology of heart failure. This study examined histopathological changes in myocardial tissue from a post-mortem cadaver with heart failure. Two age-matched cadavers without cardiac disease were used as controls. Ventricular tissue samples were thin-sectioned and stained for collagen deposition and cellular morphology using Masson's Trichrome and Cresyl Violet dyes. Histopathological findings showed the presence of increased collagen deposition and fibrosis in the myocardial tissue with heart failure, consistent with a stiffened myocardium. Additionally, Cresyl Violet staining showed cardiomyocyte hypertrophy compared to control samples, suggesting cellular remodeling, which is well characterized following heart failure. These findings provide further histological evidence of myocardial remodeling in heart failure, characterized by fibrosis and cardiomyocyte hypertrophy. Further quantitative analysis is needed to deepen our understanding of these pathological changes and their implications for cardiac function.
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