ArticleAfrican health sciences2024
Virologic re-suppression and the associated factors among children aged 1-9 years on Antiretroviral Therapy in The Aids Support Organization Soroti Region, Uganda: a retrospective cohort analysis.
Article in African health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Children living with HIV experience low viral load re-suppression after a high viral load compared to the rest of the population. We determined the proportion with re-suppressed viral load and associated factors among children 1-9 years on Antiretroviral Therapy (ART) in The Aids Support Organization (TASO) Soroti Region. Methods: We conducted a retrospective cohort analysis of 401 records of children that initially had high viral load > 1000copies/ml for the period January 2016 to December 2018. Modified Poisson regression was performed to determine factors associated with virologic re-suppression. Results: The prevalence of virologic re-suppression was 97/401 (24.2%). More than half, 213 (53.1%) of the children were females and 197/401 (49%) were aged between 8 and 9 years. Factors associated with virologic re-suppression were; being on protease inhibitor (PI) based regimen [APR 2.87, 95% CI 1.76-4.79], good adherence [APR1.71, 95% CI 1.22-2.51] and caregiver HIV seropositive status [APR 2.56, 95% CI 1.69-3.91]. Conclusion: Virologic re-suppression was low compared to the UNAIDS target. Taking PI-based regimen, good adherence and HIV seropositive status of the caregiver were predictors of virologic re-suppression. Close viral load monitoring of children on ART and intensified targeted adherence support to caregivers is vital to improving virologic re-suppression.
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