SynthesisFrontiers in surgery2025
Low-density pedicle screw in adolescent idiopathic scoliosis: a systematic review and meta-analysis of 1,762 patients.
Synthesis in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A Narrative Review of Implant Density and Surgical Outcomes in Adolescent Idiopathic Scoliosis.Cureus · 2026Review
- Decision-Making in the Surgical Management of Rigid Congenital Spinal Deformities: The Role of Vertebral Column Resection and Less Invasive Alternatives.Journal of clinical medicine · 2026Article
- Correction of deformity from convexity in adolescent idiopathic scoliosis.Journal of spine surgery (Hong Kong) · 2026Article
- Advances in fusion level selection and surgical approaches for adolescent idiopathic scoliosis based on the Lenke classification system: a narrative review.BMC surgery · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: High-density pedicle screws provide satisfactory correction in adolescent idiopathic scoliosis (AIS) but add to the operative time, blood loss, and cost; low-density constructs may mitigate these burdens and achieve similar correction results. Studies use inconsistent density cutoffs (most often <1.6 screws/level) and report conflicting results; therefore, we performed a systematic review and meta-analysis to clarify the clinical, radiographic, and economic impact of low screw density in patients with AIS. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. The PubMed, Web of Science, and Embase databases were searched until December 2024 for comparative studies. The outcomes analyzed included surgical and safety parameters (blood loss, operative time, revision rates, and complications), radiographic outcomes (Cobb angle, correction rate, and thoracic kyphosis), and implant costs. Statistical analyses were performed using RevMan 5.4, with fixed- or random-effects models applied on the basis of heterogeneity ( Results: Twenty-one studies comprising 1,762 patients met the inclusion criteria. Low-density screws were superior in reducing blood loss [mean difference (MD) = -88.06, Conclusion: Compared with high-density screws, low-density pedicle screws provide comparable radiographic and safety outcomes while reducing the operative time, blood loss, and cost. These findings support the use of low-density constructs in AIS surgery, although the variability in study designs and screw density definitions warrants further research. Future multicenter randomized controlled trials are needed to refine the optimal screw density strategies for treating AIS. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251088403, PROSPERO CRD420251088403.
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Registered trials
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