Evidence map›Paper›PMID 40809492›Full record

ArticleFrontiers in systems biology2023

The development of an ingestible biosensor for the characterization of gut metabolites related to major depressive disorder: hypothesis and theory.

Amanda Densil, Mya Elisabeth George, Hala Mahdi, Andrew Chami, Alyssa Mark, Chantal Luo, Yifan Wang, Aribah Ali, Pengpeng Tang, Audrey Yihui Dong and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in systems biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Amanda DensilFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Mya Elisabeth GeorgeFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Hala MahdiFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Andrew ChamiFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Alyssa MarkFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Chantal LuoFaculty of Engineering, McMaster University, Hamilton, ON, Canada.
Yifan WangFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Aribah AliFaculty of Humanities, McMaster University, Hamilton, ON, Canada.
Pengpeng TangFaculty of Science, McMaster University, Hamilton, ON, Canada.
Audrey Yihui DongFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Sin Yu PaoFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Rubani Singh SuriFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Isabella ValentiniFaculty of Science, McMaster University, Hamilton, ON, Canada.
Lila Al-ArabiW Booth School of Engineering Practice and Technology, McMaster University, Hamilton, ON, Canada.
Fanxiao LiuFaculty of Engineering, McMaster University, Hamilton, ON, Canada.
Alesha SinghFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Linda WuFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Helen PengFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Anjana SudharshanFaculty of Science, McMaster University, Hamilton, ON, Canada.
Zoha NaqviFaculty of Humanities, McMaster University, Hamilton, ON, Canada.
Jayda HewittArts and Science Program, McMaster University, Hamilton, ON, Canada.
Catherine AndaryFaculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Vincent LeungDepartment of Chemical Engineering, Faculty of Engineering, McMaster University, Hamilton, ON, Canada.
Paul ForsytheDivision of Pulmonary Medicine, Department of Medicine, Faculty of Medicine and Dentistry, Alberta Respiratory Centre, University of Alberta, Edmonton, AB, Canada.
Jianping XuDepartment of Biology, Faculty of Science, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnostic process for psychiatric conditions is guided by the Diagnostic and Statistical Manual of Mental Disorders (DSM) in North America. Revisions of the DSM over the years have led to lowered diagnostic thresholds across the board, incurring increased rates of both misdiagnosis and over-diagnosis. Coupled with stigma, this ambiguity and lack of consistency exacerbates the challenges that clinicians and scientists face in the clinical assessment and research of mood disorders such as Major Depressive Disorder (MDD). While current efforts to characterize MDD have largely focused on qualitative approaches, the broad variations in physiological traits, such as those found in the gut, suggest the immense potential of using biomarkers to provide a quantitative and objective assessment. Here, we propose the development of a probiotic

Indexed as

gene editinggut brain axisgut microbiomeingestible biosensormajor depressive disorderpersonalized healthcare

Identifiers

PMID40809492
PMCPMC12342046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.