Evidence map›Paper›PMID 40809452›Full record

ArticleLancet regional health. Americas2025

Environmental justice index and prevalence of asthma and COPD in US neighborhoods- a population-based study.

Sumanth Khadke, Vidhatri Khadke, Ashish Kumar, Bhargav Makwana, Sourbha S Dani, Sadeer Al-Kindi, Sanjay Rajagopalan, Yixin Kong, Khurram Nasir, Gary Adamkiewicz and 4 more

Abstract read
In one paragraph

Article in Lancet regional health. Americas, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Targeted LC-MS/MS method for quantifying respiratory pharmaceuticals in wastewater.Environmental science : water research & technology · 2026
    Article
  3. Neighborhood Determinants of Health as a Composite Index: Comparing Area-Based Indices in Public Health Research.Journal of urban health : bulletin of the New York Academy of Medicine · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sumanth KhadkeDivision of Cardiovascular Medicine, Department of Internal Medicine, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, USA.
Vidhatri KhadkeCenter for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA.
Ashish KumarDepartment of Cardiology, Mayo Clinic, Rochester, USA.
Bhargav MakwanaDivision of Cardiovascular Medicine, Department of Internal Medicine, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, USA.
Sourbha S DaniDivision of Cardiovascular Medicine, Department of Internal Medicine, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, USA.
Sadeer Al-KindiCenter for Health and Nature, and the Division of Cardiovascular Prevention and Wellness, Houston Methodist, Houston, TX, USA.
Sanjay RajagopalanHarrington Heart and Vascular Institute, University Hospitals and Case Western Reserve School of Medicine, Cleveland, OH, USA.
Yixin KongDivision of Cardiovascular Medicine, Department of Internal Medicine, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, USA.
Khurram NasirCenter for Health and Nature, and the Division of Cardiovascular Prevention and Wellness, Houston Methodist, Houston, TX, USA.
Gary AdamkiewiczDepartment of Environmental Health, Harvard T.H. Chan, School of Public Health, Boston, MA, USA.
Anju NohriaCardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.
Timothy N LieschingDivision of Pulmonary Medicine, Department of Medicine, Lahey Hospital & Medical Center, Burlington, MA, USA.
Sarju GanatraDivision of Cardiovascular Medicine, Department of Internal Medicine, Lahey Hospital & Medical Center, 41 Mall Road, Burlington, MA, USA.
Victor Pinto-PlataDivision of Pulmonary Medicine, Department of Medicine, Lahey Hospital & Medical Center, Burlington, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The independent effects of social and environmental factors on asthma and chronic obstructive pulmonary disease (COPD) are well-documented, but less is known about their combined impact across US neighborhoods. This study aimed to determine the combined and individual associations of neighborhood-level social vulnerability and environmental burden with the prevalence of asthma and COPD. Methods: This cross-sectional study analyzed 71,677 US census tracts, linking the 2022 CDC Environmental Justice Index (EJI) rankings and its subcomponents (environmental burden module [EBM] and social vulnerability module [SVM]) to the 2023 CDC PLACES dataset. Multivariable quasi-Poisson regression with an offset function was used to compare covariate-adjusted risk ratios of health indicators across quartiles of neighborhood socio-environmental burden. Findings: Among the 71,677 neighborhoods studied, the median proportion of females was 50.90%. The median proportions of individuals aged 18 to 44, 45 to 64, and ≥65 were 30.6%, 26.7%, and 15.3%, respectively, with 22.6% of the Hispanic population. Asthma and COPD prevalence rates increased with increasing EJI and EBM quartiles. Neighborhoods with the highest socio-environmental burden (Q4 EJI) had significantly higher rates of asthma (RR:1.102, 95% CI: 1.087-1.117, p < 0.001) and COPD (RR:1.156, 95% CI:1.141-1.172, p < 0.001) compared to neighborhoods with the lowest burden (Q1 EJI), after adjusting for covariates. Similarly, neighborhoods with the highest environmental burden (Q4 EBM) had higher rates of asthma (RR: 1.091, 95% CI: 1.064-1.118, p < 0.001) and COPD (RR:1.099, 95% CI: 1.070-1.129, p < 0.001) compared with Q1 EBM, after adjusting for SVM and other covariates. Interpretation: A higher prevalence of obstructive lung disease is associated with neighborhoods experiencing high cumulative socio-environmental burden. Environmental burden showed an independent association with asthma and COPD prevalence, even after adjusting for social vulnerability and other factors. Funding: None.

Indexed as

Asthma and COPDEnvironmental burden indexEnvironmental justice index (EJI)Social determinants of health (SDOH)Social vulnerability index

Identifiers

PMID40809452
PMCPMC12345341

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.