Evidence map›Paper›PMID 40809450›Full record

ReviewBehavioural neurology2025

Toxic Effects of Excess Vitamins A, B6, and Folic Acid on the Nervous System.

Yu Sun, Xiaofeng Yu, Yiliang Teng, Yanping Sun

Abstract readReview
In one paragraph

Review in Behavioural neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. From Fly to Human: Translational Relevance ofInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu SunDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID https://orcid.org/0009-0009-7466-3361
Xiaofeng YuDepartment of Neurology, Qingdao Eighth People's Hospital, Qingdao, China.
Yiliang TengDepartment of Neurology, Qingdao Shinan Integrated Chinese & Western Medicine Hospital, Qingdao, China.
Yanping SunDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID https://orcid.org/0009-0007-0911-6957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As one of the seven primary nutrients in the human body, vitamins are vital to maintaining good health. In recent years, there has been a completely new understanding of vitamins, and researchers have conducted more thorough investigations on them. These compounds, once viewed simply as supplemental nutrients, are now believed to play a more complex and critical role in human health. On the other hand, ingesting too much vitamins may cause negative health effects. Multiple studies have demonstrated a strong correlation between neurological problems and excessive vitamin intake. The purpose of this paper is to review the toxic effects of excessive vitamin intake on the nervous system, focusing on vitamin A and some of the B vitamins. It also analyzes the relationship between excessive vitamin intake and neurological dysfunction by reviewing the research findings in recent years, mainly including their possible mechanisms of action, clinical manifestations, and preventive measures, to provide ideas and inspiration for the subsequent clinical research.

Indexed as

Folic AcidNervous SystemNervous System DiseasesVitamin AVitamin B 6AnimalsDietary SupplementsHumansVitamin B ComplexVitaminsFolic AcidVitamin AVitamin B 6Vitamin B ComplexVitaminsfolic acidnervous systempyridoxineretinoic acidtoxicityvitamins

Identifiers

PMID40809450
PMCPMC12350011

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.