ArticleFrontiers in medicine2025
Predictors of uveitic macular edema and functional prognostic outcomes: real-life data from the international AIDA Network uveitis registry.
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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Blood-Ocular Barrier Dysfunction in Uveitis: A Bidirectional Model Linking Pathogenesis, Clinical Monitoring, and Therapeutic Opportunities.Medical sciences (Basel, Switzerland) · 2026Review
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Authors and funding
80 authors.
Jurgen SotaRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Germán Mejía-SalgadoNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Silvana GuerrieroDepartment of DiBrain, University of Bari, Bari, Italy.
Gaafar RagabUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
Stefania CostiUnit of Pediatric Rheumatology, ASST Gaetano Pini-CTO, Milan, Italy.
Maria Pia ParoliUveitis Unit, Department of Sense Organs, Eye Clinic, Sapienza University of Rome, Rome, Italy.
Andrea Hinojosa-AzaolaDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Giuseppe LopalcoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.
Luciana BredaDepartment of Paediatrics, University of Chieti-Pescara, Chieti, Italy.
Henrique Ayres Mayrink GiardiniDivision of Rheumatology, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Universidade de São Paulo, São Paulo, Brazil.
Alex FonollosaDepartment of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Barakaldo, Spain.
Maria Sole ChimentiRheumatology, Allergology, and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Antonio VitaleRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Carla GaggianoRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Blanca Aguilar-BarreraNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Laura Daniela Rodríguez-CameloNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Guillermo Arturo Guaracha-BasañezDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Mohamed Tharwat HegazyUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
Rosanna DammaccoDepartment of DiBrain, University of Bari, Bari, Italy.
Valeria AlbanoDepartment of DiBrain, University of Bari, Bari, Italy.
Eduardo Martín-NaresDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Santiago Espinosa-LugoNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Mahmoud GhanemaUnit of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.
Maria MorroneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.
Saverio La BellaDepartment of Paediatrics, University of Chieti-Pescara, Chieti, Italy.
Rafael Alves CordeiroDivision of Rheumatology, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Universidade de São Paulo, São Paulo, Brazil.
Francesco CarubbiDepartment of Life, Health and Environmental Sciences, Division of Internal Medicine and Nephrology, ASL1 Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, University of L'Aquila, L'Aquila, Italy.
Alessandro ConfortiU.O. Medicina Generale, Ospedale San Paolo di Civitavecchia, Civitavecchia, Rome, Italy.
Piero RuscittiUnit of Rheumatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Ibrahim AlMaglouthUnit of Rheumatology, Department of Medicine, King Saud University, Riyadh, Saudi Arabia.
Rosaria TalaricoUnit of Rheumatology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.
Stefano GentileschiRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Petros P SfikakisJoint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, Greece.
Valeria CaggianoRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Matteo PigaUnit of Rheumatology, Department of Medical Sciences and Public Health, University and AOU of Cagliari, Cagliari, Italy.
Adele CivinoUnit of Pediatric Rheumatology and Immunology, Vito Fazzi Hospital, Lecce, Italy.
Francesca RicciPediatric Clinic, University of Brescia and Spedali Civili di Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Brescia, Italy.
Maissa ThabetDepartment of Internal Medicine, Faculty of Medicine of Sousse, Farhat Hached University Hospital, University of Sousse, Sousse, Tunisia.
Marcello GovoniUnit of Rheumatology, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
Abdurrahman TufanDivision of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, Türkiye.
Francesca CrisafulliRheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Brescia, Italy.
Jessica SbalchieroRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Sulaiman M Al-MayoufDepartment of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Angela MauroDepartment of Biomedical and Clinical Sciences, Fatebenefratelli Hospital, Università di Milano, Milan, Italy.
Soad HashadDepartment of Rheumatology, Tripoli Children Hospital, Tripoli, Libya.
Francesca MinoiaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Alma Nunzia OlivieriDepartment of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Samar TharwatUnit of Rheumatology and Immunology, Department of Internal Medicine, Mansoura University, Mansoura, Egypt.
Maria Cristina MaggioUniversity Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
Abdelhfeez MoshrifDepartment of Rheumatology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Gian Domenico SebastianiU.O.C. Reumatologia, Ospedale San Camillo-Forlanini, Rome, Italy.
Daniela Opris-BelinskiDepartment of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Gülen HatemiDepartment of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Haner DireskeneliDepartment of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, Türkiye.
Fatma Alibaz-ÖnerDepartment of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, Türkiye.
Lampros FotisDepartment of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
José Hernández-RodríguezAutoinflammatory Diseases Clinical Unit, Department of Autoimmune Diseases, Center of the European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA), Hospital Clinic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Giovanni ContiUnit of Pediatric Nephrology and Rheumatology, Azienda Ospedaliero Universitaria (AOU) G Martino, Messina, Italy.
Piercarlo Sarzi PuttiniUnit of Rheumatology, Ospedale Sacco, Milan, Italy.
Ombretta ViapianaUnit of Rheumatology, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
Annarita GiardinaUOC Medicina Interna, Ambulatorio di Reumatologia, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy.
Patrizia BaroneDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Kalpana BabuDepartment of Uveitis and Ocular Inflammation, Prabha Eye Clinic and Vittala International Institute of Ophthalmology, Bangalore, India.
Rana Hussein AminDepartment of Opthalmology, Faculty of Medicine, Cairo University, Giza, Egypt.
Perla Ayumi Kawakami-CamposDepartment of Ophthalmology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Vishali GuptaAdvanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Annamaria IagnoccoAcademic Rheumatology Center, Dipartimento Scienze Cliniche e Biologiche, Università Degli Studi di Torino, Turin, Italy.
Ali ŞahinDivision of Rheumatology, Department of Internal Medicine, Sivas Cumhuriyet University Medical Faculty, Sivas, Türkiye.
Antonella InsalacoDivision of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Rome, Italy.
Andrés González-GarcíaDepartment of Internal Medicine, Autoimmune and Rare Diseases Unit, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, IRYCIS, Madrid, Spain.
Ezgi Deniz BatuUnit of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, Türkiye.
Ester CarreñoDepartment of Ophthalmology, Fundación Jiménez Díaz University Hospital (FJD), Madrid, Spain.
Emanuela Del GiudiceUnit of Pediatric and Neonatology, Department of Maternal Infantile and Urological Sciences, University of Rome La Sapienza, Rome, Italy.
Cecilia Beatrice ChighizolaDepartment of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan, Milan, Italy.
Fabrizio ContiUnit of Rheumatology, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Alberto BalistreriBioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Bruno FredianiRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Luca CantariniRheumatology Unit, Department of Medical Sciences, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Alejandra de-la-TorreNeuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.
Claudia FabianiUnit of Ophthalmology, Department of Medicine, Surgery, and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To detect factors capable of predicting the development of macular edema (ME) throughout the disease course in patients affected by non-infectious uveitis (NIU). Methods: Predictive factors leading to the development of ME were analyzed through regression analysis. The functional impact of ME on best corrected visual acuity (BCVA) was also examined. Results: A total of 1,160 NIU patients (1,857 eyes) were analyzed. ME was observed in 148 (12.76%), affecting 211 eyes. It was significantly more frequent in patients with non-anterior NIU ( Conclusion: ME can develop across all NIU types, but is more likely in cases involving the posterior segment and retinal vasculitis. Regular and focused monitoring is recommended for these high-risk patients. The study also highlights the limited predictive value of demographic and HLA-related factors, helping refine clinical risk stratification and predictive modeling in NIU.
Indexed as
macular edemaregistriesretinal vasculitisuveitisvisual acuity
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