ArticleFrontiers in medicine2025
Association between systemic immune-inflammation index and latent tuberculosis infection: a cross-sectional study.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Commentary: Impact of systemic immune-inflammation index and systemic inflammation response index on all-cause and cause-specific mortality: a community-based cohort study.Frontiers in medicine · 2026Article
- The Role of Systemic Immune-Inflammation Index and Prognostic Nutritional Index in Predicting Outcomes of Chinese Patients with Diabetic Foot Ulcers After Moist Exposed Burn Ointment Treatment.International journal of general medicine · 2026Article
- Association of logarithmic lymphocyte-albumin product with active tuberculosis in children and adolescents.Frontiers in nutrition · 2026Article
- The Impact of Body Mass Index on Latent Tuberculosis Infection: Combined Assessment in People Living with HIV.Pathogens (Basel, Switzerland) · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Background: The systemic immune-inflammation index (SII) has been associated with various diseases, but its relationship with latent tuberculosis infection (LTBI) remains unclear. This study aimed to evaluate the association between SII and LTBI in United States adults. Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2011-2012 cycles. LTBI was defined as a positive result on either the QuantiFERON Results: A total of 9,489 participants were included, among whom 1,068 were identified with LTBI. Multivariable logistic regression demonstrated that SII was inversely associated with LTBI. For each 100-unit increase in SII, the odds of LTBI decreased by 6% (adjusted OR = 0.94, 95% CI: 0.90-0.97). When analyzed by quartiles, participants in the highest quartile had significantly lower odds of LTBI compared to those in the lowest quartile (adjusted OR = 0.58, 95% CI: 0.41-0.81), with a significant trend across quartiles ( Conclusion: SII was inversely associated with LTBI and may serve as a readily accessible marker for LTBI risk stratification. Given its non-specific nature, further longitudinal studies are needed to validate its clinical and public health utility.
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