ArticleAJOG global reports2025
Prospective determination of heat shock protein serum levels in Saskatchewan women during pregnancy.
Article in AJOG global reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe stress proteins, heat shock protein 27, heat shock protein 70, and αB-crystallin, have all been detected in human serum under normal and disease conditions. Heat shock protein 70 serum levels are known to increase in women with advancing pregnancy, but heat shock protein 27, heat shock protein 70, and αB-crystallin have never been assessed prospectively in pregnancy and labor.
objectiveThis study aimed to determine the serum levels of heat shock protein 27, heat shock protein 70, and αB-crystallin in women during pregnancy to assess whether the levels increase significantly over time and particularly at term and/or labor. STUDY
designA prospective cohort pilot study of serum levels of heat shock protein 27, heat shock protein 70, and αB-crystallin in Saskatoon-area women with singleton pregnancies using enzyme-linked immunosorbent assays was conducted. Serum samples were collected from each patient at 3 periods: <14 weeks of gestation, 22 to 33 weeks of gestation at glucose screening, and at term nonlabor/active labor. The enzyme-linked immunosorbent assay data were subjected to D'Agostino and Pearson tests for normality. If data were not normally distributed, Friedman tests followed by Dunn multiple comparisons tests were performed. If data were normally distributed, they were subjected to repeated measures one-way analysis of variance, followed by Tukey multiple comparisons tests. In addition, a Spearman correlation analysis of heat shock protein levels with increasing gestational age was performed. All data were assessed and graphed using GraphPad Prism software.
resultsHeat shock protein 27 levels were significantly elevated at term/labor compared with the 2 earlier time points assessed (Dunn multiple comparisons test:
conclusionSerum levels of heat shock protein 27 and heat shock protein 70 in pregnant women at term and/or labor were significantly elevated relative to earlier periods of pregnancy, and serum levels positively correlated with gestational age. However, heat shock protein 27 levels were also significantly elevated at term compared with at labor, thereby identifying this small heat shock protein as a candidate biomarker of impending labor. Such a biomarker could be valuable for screening term pregnant women in rural settings who are distant from urban delivery centers to minimize travel, economic costs, and maternal stress.
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