SynthesisFrontiers in physiology2025
3D printed scaffolds loaded with BMP-2 for bone defect regeneration: a systematic review and meta-analysis.
Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Dose-Dependent Osteoinduction by rhBMP-2-Loaded β-Tricalcium Phosphate Scaffolds in Rabbit Critical-Sized Calvarial Defects: Histological, Histomorphometric, CD31 Immunohistochemical Evaluation.International journal of molecular sciences · 2026Article
- Osteogenic Potential of 3D Bioprinted Collagen Scaffolds Enriched with Bone Marrow Stromal Cells, BMP-2, and Hydroxyapatite in a Rabbit Calvarial Defect Model.Journal of functional biomaterials · 2026Article
- What's New in Hand Surgery: Transformative advancements and Emerging Trends.Orthopedic reviews · 2026Article
- Bifunctional scaffolds: strategic bridges coordinating osteosarcoma therapy and bone regeneration.Frontiers in bioengineering and biotechnology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Three-dimensional (3D) printing technology and bone morphogenetic protein- 2 (BMP-2) represent promising strategies for promoting bone regeneration. Objectives: This systematic review aims to assess the effects of 3D printed scaffolds loaded with BMP-2 on bone regeneration in preclinical studies. Methods: We conducted a search in the PubMed, Web of Science, and Embase databases. Based on the inclusion and exclusion criteria, we selected and evaluated original research articles investigating on the effects of 3D printed scaffolds loaded with BMP-2 Results: BMP-2 loaded 3D printed scaffolds significantly increased both the bone volume to total volume ratio (BV/TV) [2.15 (1.14, 3.16)], the percentage of new bone volume [3.07 (1.86, 4.28)], and the percentage of new bone area [3.93 (1.51, 6.35)]. Conclusion: Preclinical evidence substantiates the capacity of BMP-2- functionalized 3D-printed scaffolds to promote bone regeneration through spatially controlled osteoinductive signaling. These findings provide important insights for the future application of such scaffolds in bone regeneration or repair in subsequent research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.