ArticleFrontiers in physiology2025
Concurrent training and intermittent fasting reduce transverse cross-sectional area of cardiomyocytes and body mass in Wistar rats.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods: This study identified the alterations caused by concurrent training and intermittent fasting on the myocardium of rats. In total, 39 adult male Wistar rats were used, divided into four groups: control [C (n = 12)], fasting control [FC (n = 11)], training [T (n = 8)], and fasting training [FT (n = 8)]. The critical load test was performed to evaluate and determine the intensity of effort in aerobic training (AT) (swimming). The resistance training protocol (RT) (anaerobic) consisted of four series of 10 jumps, with overload corresponding to 50% of the body mass of each animal, and 1 min of rest between each series. The concurrent training (CT) was composed of a protocol of AT and RT in the same session. The intermittent fasting period was 12/12 h. At the end of the experiment, the animals were weighed to obtain the Lee index; heart weight was verified, and tissue samples were collected for further histological analysis. After obtaining the data, the Shapiro-Wilk test was performed, followed by a two-way analysis of variance (ANOVA) with Tukey's post-test for the variables measured at the end of the experiment. Results: For the variables body mass, feed consumption, and the anaerobic threshold, the FC group showed a greater decrease in the Lee index [(0.28 ± 0.00) p < 0.05)] in relation to the other groups. There were no significant alterations (p > 0.05) in relation to heart weight, fractal dimension, and anaerobic threshold (AnT); finally, both the T and the FT groups presented a significant decrease ([T: (277.3 ± 119.3/FT: 310.5 ± 148.8] p < 0.05) in the transverse cross-sectional area of the cardiomyocytes, when compared to the control groups. Conclusion: The practice of concurrent training for a period of 4 weeks precipitated a decrease in the transverse cross-sectional area of the cardiomyocytes of Wistar rats. Furthermore, when combined with intermittent fasting, concurrent training not only led to a reduction in the transverse cross-sectional area of the cardiomyocytes but also resulted in a decrease in body mass compared to the isolated concurrent training model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.