ArticleJournal of thoracic disease2025
Predictive role of tumor-infiltrating lymphocytes and immune phenotype for pembrolizumab in relapsed or refractory thymic carcinoma.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pembrolizumab is a promising treatment option for platinum-failed thymic carcinoma; however, the lack of established predictive biomarkers remains a challenge. Therefore, this study aimed to assess the predictive value of artificial intelligence (AI)-powered tumor-infiltrating lymphocyte (TIL) analysis of pembrolizumab for thymic carcinoma. Methods: Patients with platinum-failed, advanced thymic carcinoma treated with pembrolizumab between January 2016 and December 2021 were included. Hematoxylin and eosin-stained sections from the samples closest to the time before pembrolizumab treatment were analyzed using an AI-powered TIL analyzer. Intratumoral TIL (iTILs) and stromal TIL (sTILs) were quantified, and their immune phenotypes (IP) were identified. Results: In total, 10 patients were included in this study. The best response was complete response in 1 patient (10%) and partial response in 1 patient (10%). The median progression-free survival (PFS) was 5.0 months. Patients with higher iTIL (>27.23/mm Conclusions: Increased infiltration of both iTIL and sTIL is associated with longer PFS and OS. Additionally, an inflamed IP is associated with longer PFS. Thus, TIL density and IP may be promising predictive biomarkers for pembrolizumab in patients with platinum-failed thymic carcinoma.
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