ArticleJournal of thoracic disease2025
Enhancement of anti-programmed cell death protein-1 immunotherapy in non-small cell lung cancer using arginine and citrulline supplementation.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Immune checkpoint inhibitors (ICIs) have substantially improved outcomes in previously untreatable cancer cases, but their effectiveness as monotherapies is limited. In this study, we examined the role of citrulline in the lung cancer microenvironment and its potential synergistic effects with immunotherapy. Methods: Murine lung cancer cells (CMT167) were subcutaneously implanted in mice to establish tumor models, which were then treated with the anti-programmed death 1 (PD-1) antibody either alone or in combination with arginine or arginine and citrulline. Tumor growth, survival rate, cytokine levels, immune cell populations, and metabolic marker expression were assessed using histological, immunostaining, flow cytometry, and serum analyses. Results: Mice in the treatment groups exhibited significantly lower tumor volumes than those in the control group (control, 1,161.59±294.73 mm Conclusions: Arginine and citrulline supplementation facilitated CD8
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