ArticleIranian journal of basic medical sciences2025
Estrogen and progesterone attenuate CD4-positive immune cell traffic to the penumbra region of rat's ischemic stroke brain.
Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Serum iron as a biomarker for "penumbra freezing" in patients with acute ischemic stroke.Frontiers in neuroscience · 2025Article
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6 authors.
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Abstract
Objectives: Stroke is an acute cerebrovascular disease with a high incidence, high disability rate, and high mortality. Stroke damages the integrity of the blood-brain barrier. Immune cells are concerned with multiple facets of ischemic stroke; peripheral immune cells, including neutrophils, T cells, B cells, and macrophages, infiltrate the ischemic brain tissue and are essential in regulating the progression of ischemic brain damage. The current study investigated the effects of estrogen and progesterone (PROG) hormones (E/P) on the expression of CD4 Materials and Methods: Stroke was induced in male adult rats by transient middle cerebral artery occlusion (tMCAO). Rats were collected 24 hr after reperfusion, and then the doses of estrogen and progesterone were administered two hours after tMCAO. The expression of CD4 Results: CD4 Conclusion: The results of the present study showed that induction of tMCAO altered the expression of CD4
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