Evidence map›Paper›PMID 40809105›Full record

ArticleACS applied polymer materials2025

Antibacterial Creams Containing Cationic Carbosilane Dendrimers for Wound Treatment.

Rebeca Lozano-García, Sara Quintana-Sánchez, Selma Benito-Martínez, Guillermo Torrado, Víctor Guarnizo-Herrero, Borja Martínez-Alonso, Gemma Pascual, Bárbara Pérez-Köhler, Javier Sánchez-Nieves, F Javier de la Mata

Abstract read
In one paragraph

Article in ACS applied polymer materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebeca Lozano-GarcíaUniversidad de Alcalá (UAH), Departamento de Química Orgánica y Química Inorgánica, Edificio de Farmacia, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0002-3050-4862
Sara Quintana-SánchezUniversidad de Alcalá (UAH), Departamento de Química Orgánica y Química Inorgánica, Edificio de Farmacia, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.
Selma Benito-MartínezNetworking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Guillermo TorradoUniversidad de Alcalá (UAH), Departamento de Ciencias Biomédicas, Facultad de Farmacia, Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.
Víctor Guarnizo-HerreroUniversidad de Alcalá (UAH), Departamento de Ciencias Biomédicas, Facultad de Farmacia, Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0001-9323-3388
Borja Martínez-AlonsoUniversidad de Alcalá (UAH), Departamento de Ciencias Biomédicas, Facultad de Farmacia, Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.ORCID https://orcid.org/0009-0002-9124-5507
Gemma PascualNetworking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Bárbara Pérez-KöhlerNetworking Research Centre for Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Javier Sánchez-NievesUniversidad de Alcalá (UAH), Departamento de Química Orgánica y Química Inorgánica, Edificio de Farmacia, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0003-0410-2285
F Javier de la MataUniversidad de Alcalá (UAH), Departamento de Química Orgánica y Química Inorgánica, Edificio de Farmacia, Research Institute in Chemistry "Andrés M. del Río" (IQAR), Campus Universitario, 28805 Alcalá de Henares, Madrid, Spain.ORCID https://orcid.org/0000-0003-0418-3935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin wounds are an important factor in developing bacterial infection, especially for chronic wounds. In this case, the exposure to long traditional antibacterial-based treatments can lead to the appearance of resistance to these drugs. This situation makes the search for alternatives to attack these infections essential, as it is the use of cationic multivalent systems. Here, we discussed the antibacterial and biological properties of different cationic carbosilane (CBS) dendrimers against () and () as models of Gram-positive and Gram-negative bacteria, respectively. Dendrimers are a type of multivalent molecule with a well-defined structure. The CBS dendrimers used in this work differ in several modifications that affect the hydrophobic/hydrophilic balance, which is very relevant to achieve bactericidal activity. These structural changes are the position of a short alkyl chain, in the internal dendritic structure or on the outer ammonium groups, the presence of a polyethylene glycol (PEG) chain instead of a cationic function, or in the vicinal moieties of the cationic functions, sulfur atoms or sulfone units. The studies allowed the selection of some dendrimers, all of them with the inner long chain and trimethylammonium (-NMe

Indexed as

antibacterialcarbosilane dendrimerquaternary ammoniumskin woundtopical cream

Identifiers

PMID40809105
PMCPMC12340762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.