Evidence map›Paper›PMID 40809083›Full record

ArticleMechanobiology in medicine2025

Piezo1 activates nitric oxide synthase in red blood cells via protein kinase C with increased activity in diabetes.

Gurneet S Sangha, Lauren V Smith, Marzyeh Kheradmand, Kashif M Munir, Nimisha Rangachar, Callie M Weber, Zohreh Safari, Stephen C Rogers, Allan Doctor, Alisa Morss Clyne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanobiology in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Geraniol Exerts Cytotoxic Effects in Red Cells Through CaMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gurneet S SanghaFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.
Lauren V SmithFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.
Marzyeh KheradmandFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.
Kashif M MunirDivision of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 800 Linden Avenue, Baltimore, MD, 21201, USA.
Nimisha RangacharFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.
Callie M WeberFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.
Zohreh SafariCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA.
Stephen C RogersCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA.
Allan DoctorCenter for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA.
Alisa Morss ClyneFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Dr, College Park, MD, 20742, USA.

Funding

SEPSIS-INDUCED RED CELL DYSFUNCTION (SIRD)R01GM113838 · NIGMS · WASHINGTON UNIVERSITY · PI DOCTOR, ALLAN, MARSHALL, GARLAND ROSS · 2015 to 2019
$4.0M
Metabolic interactions in the vascular wall: an integrated experimental and computational approachR01HL165193 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI Alisa S Morss Clyne, Ganesh Sriram · 2023 to 2026
$2.9M
Red blood cell ATP export and transfusion in sepsisR01HL161071 · NHLBI · DUKE UNIVERSITY · PI Allan Doctor, TIMOTHY J MCMAHON · 2023 to 2026
$2.7M
The effect of laminar and disturbed flow on endothelial glucose metabolismR01HL140239 · NHLBI · UNIV OF MARYLAND, COLLEGE PARK · PI MORSS CLYNE, ALISA S · 2018 to 2022
$1.9M
NHLBI NIH HHS R01 HL140239NHLBI NIH HHS R01 HL161071NHLBI NIH HHS R01 HL165193NIGMS NIH HHS R01 GM113838
6 · The paper itself

Abstract

Nitric oxide (NO) is a key signaling molecule in maintaining cardiovascular health. While endothelial cells were initially thought to exclusively contain endothelial nitric oxide synthase (eNOS), an enzyme that produces NO, recent evidence suggests that red blood cells (RBC) also contain functional eNOS that impacts cardiovascular function. However, the mechanisms driving RBC eNOS activation are not well understood. Like endothelial cells, RBC are mechanosensitive via the stretch-activated piezo1 Ca

Indexed as

DiabetesMechanobiologyNitric oxidePiezo1Protein kinase cRed blood cells

Identifiers

PMID40809083
PMCPMC12344281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.