Evidence map›Paper›PMID 40809058›Full record

ArticleFrontiers in microbiology2025

Synthetic niclosamide-loaded controlled-release nanospheres with high solubility and stability exerting multiple effects against

Yulei Tai, Meng Zhang, Yuning Han, Hui Hu, Shan Lin, Fangya Zhai, Menglun Tian, Xiaojun Song, Shuangshuang Wan, Yu Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yulei TaiSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Meng ZhangSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yuning HanSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Hui HuSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Shan LinSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Fangya ZhaiSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Menglun TianSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xiaojun SongDepartment of clinical laboratory, Hangzhou Medical College, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou, Zhejiang, China.
Shuangshuang WanSchool of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yu Chen *School of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Dazhi Jin *School of Laboratory of Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Niclosamide (NIC) has significant potential as a clinical therapeutic agent for Methods: Niclosamide-loaded controlled-release hyaluronic acid-modified poly (lactic- Results: NIC@PLGA-HAs exhibited enhanced solubility and stability, with a water contact angle on a hydrophilic surface of 65.1° and a zeta potential of 31.57 ± 2.08 mV, and pH-responsive (pH 7.4) controlled-release characteristics compared to free NIC. The NIC@PLGA-HAs killed Conclusion: These findings presented the therapeutic potential of NIC@PLGA-HAs with high solubility and stability, which simultaneously exerted multiple biological activities against

Indexed as

biofilm formationClostridioides difficileloaded controlled-release nanospheresmultiple effectsNiclosamidespore germination

Identifiers

PMID40809058
PMCPMC12343512

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.