ArticleFrontiers in oncology2025
Ansofaxine Hydrochloride inhibits hepatocellular carcinoma growth and enhances targeted therapy through the EGFR/MAPK pathway.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Hepatocellular carcinoma (HCC) is a common tumor that endangers health. Depression will affect the therapeutic effect of HCC, and depression and HCC promote and influence each other. Ansofaxine Hydrochloride is a novel antidepressant, and its anti-HCC effect remains to be confirmed. Objectives: This study aimed to investigate the effect of Ansofaxine Hydrochloride on HCC and its molecular mechanism. Methods: The potential targets and signaling pathways of Ansofaxine Hydrochloride against HCC were obtained by network pharmacology, and the key targets were explored by molecular docking techniques. Hepatocellular carcinoma cells were treated with different concentrations of Ansofaxine Hydrochloride, and the effects of Ansofaxine Hydrochloride on the biological function of hepatocellular carcinoma cells were evaluated by CCK8, migration, invasion, and clonal formation tests. Subsequently, a subcutaneous hepatocellular carcinoma mouse model was established to evaluate the effect of Ansofaxine Hydrochloride on the growth of hepatocellular carcinoma tissue Results: There are 87 common drug-disease targets between Ansofaxine Hydrochloride and HCC, including EGFR, GRB2, and SRC, which are mainly involved in EGFR, MAPK, and PI3K/AKT signaling pathways. Molecular docking showed that Ansofaxine Hydrochloride has good binding activity to EGFR, GRB2, and other key targets. Conclusion: Our study suggests that Ansofaxine Hydrochloride has anti-HCC and immunomodulatory effects, with the EGFR/MAPK pathway as a potential key mechanism of action.
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