MicroRNAs in circulating extracellular vesicles as biomarkers of early colorectal cancer captured using high mannose

Sanae Nakayama, Miyabi Umeda, Kenya Kobayashi, Yukiko Nakano, Kanji Hori, Tsukuru Umemura, Hiroshi Kurokawa

Abstract read

In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Lectin-captured plasma microRNAs predict response and survival in patients with non-small cell lung cancer treated with nivolumab.Oncology letters · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sanae NakayamaR&D Department, Alps Alpine Co., Ltd, Osaki, Japan.

Miyabi UmedaR&D Department, Alps Alpine Co., Ltd, Osaki, Japan.

Kenya KobayashiR&D Department, Alps Alpine Co., Ltd, Osaki, Japan.

Yukiko NakanoLaboratory of Marine Bioresource Chemistry, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.

Kanji HoriLaboratory of Marine Bioresource Chemistry, Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima, Japan.

Tsukuru UmemuraGraduate School, Department of Medical Technology and Sciences, International University of Health and Welfare, Okawa, Japan.

Hiroshi KurokawaR&D Department, Alps Alpine Co., Ltd, Osaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lectin (OAA), isolated from the filamentous cyanobacterium Methods: OAA1 (a recombinant OAA variant) was used to capture HM Results: OAA1 effectively captured HM Discussion: These results suggest that circulating miRNAs in OAA1-captured EVs could serve as biomarkers for the surveillance of early stage CRC using liquid biopsy. The OAA1-immobilized column device facilitates easier and quicker inspection processes and accentuates differences in circulating miRNAs associated with the disease. Conclusion: OAA1-column showed potential clinical application to analyze circulating EVs and miRNAs associated with CRC, serving as a relevant liquid biopsy for early cancer detection.

Indexed as

biomarkercolorectal cancerextracellular vesiclehigh-mannose type N-linked glycanlectinliquid biopsymiRNAOAA

Identifiers

PMID40809019

DOI10.3389/fonc.2025.1619460

PMCPMC12343284

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.