ReviewFrontiers in oncology2025
Synergistic strategies in photodynamic combination therapy for cancer: mechanisms, nanotechnology, and clinical translation.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Coumarin and Curcumin-Metal Complexes as Next-Generation Photosensitizers in Cancer Photodynamic Therapy.International journal of molecular sciences · 2026Review
- Liposome-Based Photodynamic Therapy for Breast Cancer: Innovations in Targeted Delivery, Combination Strategies, and Clinical Translation.International journal of molecular sciences · 2026Review
- Photo-immunotherapeutic PDA-Ce6-R837 nanoparticles enhance the induction of immunogenic responses in melanoma cells.RSC advances · 2026Article
- Photodynamic Therapy Combined with Anticancer Drug Therapy in the Treatment of Malignant Neoplasms.Cells · 2026Review
- Bioinspired Natural Product Nanoplatforms for Precision Cancer Theranostics from Nature to Nanomedicine.International journal of nanomedicine · 2026Review
- Light as a Weapon: Redefining Cancer Care with Photodynamic Therapy.International journal of biological sciences · 2026Review
- Editorial: Synergistic effects of PDT and RT in cancer treatment: innovations and challenges.Frontiers in oncology · 2026Article
- Recent Advances in Antitumor Nanomedicine Based on Covalent Organic Frameworks.International journal of nanomedicine · 2026Review
- Lanthanide Nanotheranostics in Radiotherapy.International journal of molecular sciences · 2025Review
- Advancing Lung Cancer Treatment: A Comprehensive Review of Photodynamic Therapy and Nanoparticle Applications.Pharmaceutics · 2025Review
- Optimization of Photodynamic Therapy in Dermatology: The Role of Light Fractionation.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT), a non-invasive and highly selective method for cancer treatment, has gained increasing attention due to its unique ability to activate a photosensitizer with near-infrared laser irradiation, generating reactive oxygen species (ROS) and inducing cytotoxic effects on tumors. However, PDT faces challenges such as the shallow penetration depth of the laser impacting treatment efficacy and the variability in ROS yield depending on various factors. Recent advancements in nanotechnology have paved the way for solutions, showing promising results in addressing these limitations. Therefore, there is rising interest in utilizing PDT in combination with other therapeutic modalities to enhance its anti-tumor efficacy. This review aims to compile relevant basic experiments and clinical studies on the principles, mechanisms, and various combination therapies of PDT, including with photothermal therapy, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. The findings from these studies consistently confirm that photodynamic combination therapy achieves a higher therapeutic index with lower side effects compared to the use of these modalities individually. The demonstrated synergistic effects and enhanced therapeutic outcomes in various studies underscore the need for additional research and development in this direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.