SynthesisFrontiers in oncology2025
Impact of lymph node dissection on the prognosis of intrahepatic cholangiocarcinoma: a systematic review and meta-analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Tumor Burden Modifies the Prognostic Impact of Adequate Lymph Node Dissection in Patients Undergoing Curative-Intent Resection for Intrahepatic Cholangiocarcinoma.Annals of surgical oncology · 2026Article
- Lymph Node Dissection in Biliary Tract Cancers: Time for a Rethink?Annals of surgical oncology · 2026Article
- Hot Topics in the Surgical Treatment of Intrahepatic Cholangiocarcinoma: A Narrative Review of Current Managements.Cancers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intrahepatic cholangiocarcinoma (iCCA) is a malignant tumor second only to hepatocellular carcinoma in terms of incidence among primary liver cancers. Surgical resection is currently the preferred treatment for iCCA. However, the prognostic significance, complications, and clinical benefits of lymph node dissection (LND) in iCCA patients remain a topic of debate within the academic community. Methods: To evaluate the impact of LND on overall survival (OS) and prognosis in patients with resectable iCCA, studies published from various databases, including PubMed, Embase, Web of Science, and the Cochrane Library. A meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The impact of LND on prognosis was analyzed. Results: A total of 5,787 patients from twenty-one retrospective cohorts were included in the final analysis. The results indicated that clinically node-negative patients who underwent LND had significantly better survival outcomes compared to those who did not undergo LND ( Conclusion: Patients with resectable iCCA who underwent LND had better survival outcomes compared to those who did not undergo LND. Therefore, routine LND should be performed for clinically lymph node-negative (cLNM-) iCCA patients. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024564741.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.