ArticleFrontiers in nutrition2025
The role of body composition, cardiometabolic parameters, and resting substrate oxidation in protecting against metabolic syndrome in adolescents with obesity.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Association between the Glucose-to-potassium ratio and prognosis in critically ill patients with sepsis and malignancy: a retrospective study based on the MIMIC database.BMC infectious diseases · 2026Article
- Evaluation of nutritional interventions and their impact on metabolic syndrome risk markers in older adults.Frontiers in nutrition · 2026Article
- Fractal Analysis of Intramuscular Adipose Tissue on CT Serves as a Novel Imaging Biomarker for Metabolic Syndrome.International journal of medical sciences · 2026Article
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14 authors.
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Abstract
Purpose: The aetiology of metabolic syndrome (MetS) in young people involves a complex interplay between lifestyle, body composition, and cardiometabolic risk factors. The present study aimed to explore the relationships between anthropometric characteristics, body composition, cardiometabolic parameters and resting substrate metabolism in the development of MetS in severely adolescents with obesity. Methods: Seven hundred and thirty adolescents with obesity (mean age: 14.6 ± 2.1 years, BMI > 97th percentile for gender and age) were included in this study. Body composition analysis was obtained using tetrapolar bioelectrical impedance analysis (BIA), while resting substrate oxidation was measured using an indirect calorimeter. Results: MetS was present in 27% of the participants. Compared to those without MetS, adolescents with MetS had significantly higher body mass (+15 kg, Conclusion: In adolescents with severe obesity, resting carbohydrate oxidation and HOMA-IR emerged as independent risk factors for MetS, offering additional insight beyond conventional anthropometric and lipid indicators. Conversely, higher FFM and HDL cholesterol levels appeared to exert a protective effect. These findings underscore the importance of incorporating metabolic and body composition variables into MetS risk models and support the promotion of targeted interventions, such as endurance and resistance training, to address modifiable risk factors and reduce the likelihood of developing MetS.
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